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Leflunomide Coupon - Leflunomide 20mg tablet

leflunomide

Generic Arava
Used for Rheumatoid Arthritis
Used for Rheumatoid Arthritis

Leflunomide (Arava) is a non-biologic, disease-modifying antirheumatic drug (DMARD). It's used to treat rheumatoid arthritis (RA) in adults. This medication is a tablet that's taken by mouth once per day. Your care team will regularly follow up with you throughout treatment because leflunomide (Arava) can potentially cause many side effects. Common side effects include stomach upset, headache, rash, hair loss, and high blood pressure. Liver damage and severe infections are some of the rarer, but more serious, side effects.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on February 12, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Leflunomide (Arava)?

What is Leflunomide (Arava) used for?

How Leflunomide (Arava) works

Leflunomide (Arava) is a non-biologic, disease-modifying antirheumatic drug (DMARD). It blocks certain proteins and cells of the immune system that are overactive from turning on. This lowers inflammation in the joints, which helps treat symptoms and prevent joint damage in people with rheumatoid arthritis.

Are you looking for information on Revlimid (lenalidomide) or Aubagio (teriflunomide) instead?

Drug Facts

Common BrandsArava
Drug ClassDisease-modifying antirheumatic drug (DMARD)
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Leflunomide (Arava)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (27%)
  • Headache (13%)
  • Nausea (13%)
  • Rash (12%)
  • Abnormal liver labs (10%)
  • Hair thinning or hair loss (9%)
  • High blood pressure (9%)

Other Side Effects

  • Weakness or lack of energy
  • Dizziness
  • Back pain
  • Joint pain or stiffness
  • Stomach pain or upset stomach
  • Vomiting
  • Bronchitis
  • Runny nose
  • Mouth sores
  • Itchy skin

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool, confusion
  • Serious infections: fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning when you urinate, urinating more often
  • Serious allergic reactions and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes

Source: DailyMed

More on Leflunomide (Arava) side effects

Health: Leflunomide: side effects leflunomide

10 Side Effects of Arava You Need to Know

Written by Austin Ulrich, PharmD, BCACP

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bloody or cloudy urine

cough

difficult or painful breathing

difficult, burning, or painful urination

dizziness

fever

frequent urge to urinate

headache

loss of appetite

nausea or vomiting

sneezing

sore throat

tightness in the chest

yellow eyes or skin

Less common

Burning feeling in the chest or stomach

burning, prickling, or tingling sensation in the fingers or toes

chest pain

diarrhea

fast or pounding heartbeat

indigestion

joint or muscle pain or stiffness

severe stomach pain

tenderness in the stomach area

unusual tiredness or weakness

Incidence not known

Area rash

black or tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

bloating

blood in the stools

burning, numbness, tingling, or painful sensations

chills

clay-colored stools

confusion

constipation

continuing vomiting

cough or hoarseness

dark urine

fainting

fever with or without chills

general feeling of tiredness or weakness

high fever

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

lightheadedness

lower back or side pain

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

pinpoint red spots on the skin

rapid, shallow breathing

red skin lesions, often with a purple center

red, irritated eyes

sores, ulcers, or white spots in the mouth or on the lips

swollen glands

unexplained bleeding or bruising

unpleasant breath odor

unsteadiness or awkwardness

unusual bleeding or bruising

upper right abdominal or stomach pain

vomiting of blood

weakness in the arms, hands, legs, or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

hair loss

heartburn

skin rash

stomach pain

weight loss (unexplained)

Less common

Acne

anxiety

decreased appetite

dry mouth

gas

irritation or soreness of the mouth

itching of the skin

pain or burning in the throat

runny nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Leflunomide (Arava)

thumbs-up

Pros

Taken once daily by mouth

Works well to treat symptoms of RA

Available as a lower-cost generic

thumbs-down

Cons

Can cause a lot of side effects (e.g., stomach upset, infections, hair loss, liver problems, skin reactions)

Can stay in your body for a few years after you stop treatment

Can't use during pregnancy or in children

pharmacist-tips

Pharmacist tips for Leflunomide (Arava)

pharmacist

  • Mark your appointments on your calendar to see your rheumatologist and to get any lab tests done (e.g., liver tests, blood cell count, blood pressure checks). These follow-ups are important because your rheumatologist is making sure that the medication is working well for you and is checking for any side effects.

    • Take leflunomide (Arava) at the same time every day with or without food. Keep in mind that nausea and diarrhea are possible side effects, so taking it with food can help prevent or ease stomach upset.

      • Before you get any vaccines, let your primary care provider or pharmacist know that you're taking leflunomide (Arava). They can make sure the vaccine is safe for you. In general, avoid getting live vaccines during treatment. This medication weakens your immune system. This might make live vaccines work less well for you and make you get sick from the vaccine itself. After you stop leflunomide (Arava), don't get a live vaccine until your care team says you can.

        • Let your rheumatologist know if you want to stop taking leflunomide (Arava). This medication can stay in your body for up to 2 years after you've stopped taking it. When you want to stop the medication, you'll need to go through a specific process to "quickly" get rid of leflunomide from your body. This process involves taking either cholestyramine or activated charcoal for 11 days. Ask your rheumatologist for more information about stopping the medication.

          • Tell your rheumatology care team about all the medications you're taking or planning to take.Leflunomide (Arava) can interact with other medications. For example, it can cause the blood thinner warfarin (Coumadin) to work less well and raise your risk for blood clots. Additionally, taking leflunomide (Arava) with medications that weaken your immune system could raise your risk for serious infections.

            • If you or your partner is able to become pregnant, you must use birth control while you're taking leflunomide (Arava). This medication has a risk of causing severe harm to an unborn baby. Tell your rheumatologist right away if you're pregnant or thinking of getting pregnant while you're taking leflunomide (Arava).

              • It's not recommended to breastfeed while you're taking leflunomide (Arava) because the medication can potentially cause severe side effects in your baby. Talk to your rheumatologist about your options.

                faqs

                Frequently asked questions about Leflunomide (Arava)

                How toxic is leflunomide (Arava)?
                Leflunomide (Arava) can potentially cause many side effects, like headache, hair loss, nausea, diarrhea, and headache. They might get better with time as you continue to take the medication. There are also some potentially serious risks, such as liver damage, low blood cell counts, and infection. Your rheumatologist will regularly monitor you for these serious risks, for example with blood testing to check your liver function and blood cell counts. Your rheumatologist might lower your leflunomide (Arava) dose or stop treatment if it's suspected that the medication is causing serious side effects. Ask your rheumatologist or pharmacist if you have any questions about the possible risks and side effects from leflunomide (Arava).
                What pain reliever can I take with leflunomide (Arava)?
                Ask your rheumatologist or pharmacist before taking any pain medications at the same time as leflunomide (Arava). Your rheumatologist or pharmacist can check for interactions that might be harmful. For example, both acetaminophen (Tylenol) and leflunomide (Arava) can raise your risk for liver problems, so your care team might recommend you to avoid this combination. Additionally, while it's generally safe to take nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) with leflunomide (Arava), taking both medications can worsen side effects or risks that they share, like nausea, bleeding, and high blood pressure. Your care team can suggest safer ways to relieve any pain while you're taking leflunomide (Arava).
                Is leflunomide (Arava) a steroid?
                No, leflunomide (Arava) isn't a steroid; it's a disease-modifying antirheumatic drug (DMARD). Both DMARDs and steroids work to lower inflammation in the joints, but they do so in different ways.
                Does leflunomide (Arava) cause hair loss?
                Yes, leflunomide (Arava) can cause hair loss as a side effect. Contact your care team if you notice hair loss while you're taking this medication. Your care team can recommend ways to lessen or manage hair loss.
                Is leflunomide (Arava) an immunosuppressant?
                Yes, leflunomide (Arava) is an immunosuppressant, or a medication that can weaken your immune system. Leflunomide (Arava) blocks certain proteins in your immune system to make it less active and lessen inflammation in the joints. But having a less active immune system can put you at risk for serious infections. Get medical help if you think you might be sick or if you have a fever.
                How long does it take for leflunomide (Arava) to work?
                Leflunomide (Arava) can start to work as early as 4 weeks for some people. But keep in mind that it can take longer to get the maximum benefit from the medication. Also, everyone responds differently to medications, so it's possible that leflunomide (Arava) might work slower or faster for you. Contact your rheumatologist if you're not sure whether leflunomide (Arava) is helping your RA symptoms.
                Can I just stop taking leflunomide (Arava)?
                It's technically possible to just stop taking leflunomide (Arava). But don't stop taking the medication without talking to your rheumatologist first. Your RA symptoms might come back after you stop leflunomide (Arava) if it's been helping you. Also keep in mind that it can take up to 2 years for your body to completely get rid of the medication. This means that it's possible for any side effects you're having from the medication to last as long as this time frame. Discuss with your rheumatologist about stopping leflunomide (Arava). If needed, they can prescribe cholestyramine (Prevalite) or activated charcoal for you to take for 11 days to speed up the process of removing leflunomide from your body.
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                What are the risks and warnings for Leflunomide (Arava)?

                Leflunomide (Arava) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Not safe during pregnancy

                You can't take leflunomide (Arava) if you're pregnant because the medication can cause severe and life-threatening harm to an unborn baby. Your rheumatologist might ask you to do a pregnancy test before you start leflunomide (Arava) to make sure you're not pregnant.

                If you can become pregnant, you must use effective birth control while you're taking leflunomide (Arava). Let your rheumatology care team know right away if you become pregnant at any time during and even after treatment. You'll need to take specific medications to help your body get rid of leflunomide (Arava) quickly to lower the risk of harm to the baby. It's also encouraged to report the pregnancy to the manufacturer by calling 1-877-311-8972.

                risk-warning

                Liver problems

                • Risk factors: History of liver problems | Taking medications that can harm the liver

                  Some people had liver damage while they were taking leflunomide (Arava). Some cases of liver damage were severe and required a liver transplant.

                  Tell your care team about your medical history and all the medications you take or plan to take. The risk for liver damage during treatment is higher for people who already have liver problems or for people who take other medications that harm the liver. You won't be able to take leflunomide (Arava) if you have serious liver problems.

                  Your provider will monitor your liver closely through blood tests while you're taking leflunomide (Arava). They might ask you to stop leflunomide (Arava) if you have symptoms of liver damage, such as feeling more tired, having little to no appetite, having yellowing of the skin or eyes, or dark-colored urine.

                  risk-warning

                  Serious infections

                  • Risk factors: Active, chronic, or recurrent infection | Having other medical conditions that raise your risk of infection | Living in or traveling to places with high rates of infections | Taking medications that weaken your immune system

                    Leflunomide (Arava) can affect your body's ability to fight infections. This can raise your risk for serious and sometimes life-threatening bacterial, viral, or fungal infections. Before you start leflunomide (Arava), your rheumatologist will screen you for infections, such as tuberculosis (TB), to make sure the medication is safe for you to take.

                    To be safe, your rheumatologist will probably recommend a different treatment for your RA if you already have a weakened immune system because of a medical condition (e.g., cancer) or because of other medications (e.g., transplant medications).

                    Go to the hospital right away if you develop symptoms of an infection, such as fever, cough, difficulty breathing, weakness, sweating, chills, or diarrhea, while you're taking leflunomide (Arava). You should get tested for an infection and get proper treatment if needed. You might have to stop taking leflunomide (Arava) so your body can fight the infection.

                    risk-warning

                    Low blood cell counts

                    Leflunomide (Arava) can lower your blood cell counts. This means your platelet count can drop (thrombocytopenia), putting you at risk for severe bleeding. You might also be at risk for anemia. In addition, having a lower white blood cell count can raise your risk for infection.

                    Your rheumatologist will order blood draws to check your blood cell counts regularly throughout treatment. Tell your care team if you have symptoms of low platelets, like unusual bleeding, bleeding that lasts for a long time, difficulty stopping bleeds, or easy bruising. Also get medical help if you think you have an infection — look out for fever, chills, tiredness, cough, body aches, and runny nose.

                    risk-warning

                    Serious allergic reactions and skin reactions

                    Severe allergic reactions to leflunomide (Arava) are possible, including life-threatening reactions like facial swelling and anaphylaxis (e.g., closing of the throat). Though rare, this medication can also cause drug reaction with eosinophilia and systemic symptoms (DRESS), which can look like fever, rash, and swollen lymph nodes.

                    Leflunomide (Arava) can also cause sudden and serious skin reactions like Stevens-Johnson Syndrome (SJS). Symptoms can include fever, body aches, rash, peeling skin, painful blisters all over your body, and swelling of the face.

                    Stop using leflunomide (Arava) and get medical attention right away if you have any allergic reactions or skin reactions to the medication.

                    risk-warning

                    Nerve pain

                    • Risk factors: Age 60 years and older | Taking other medications that can worsen nerve pain | Diabetes

                      Leflunomide (Arava) can cause nerve pain. For most people, it goes away after stopping the medication. But a few people might continue to experience nerve pain even after they stop leflunomide (Arava). If you start having nerve pain during treatment, your rheumatologist might ask you to stop leflunomide (Arava). You might have to go through a process that helps get rid of the medication from your body quickly to ease this side effect. Contact your care team if you have any pain, numbness, or tingling in your hands or feet.

                      risk-warning

                      Lung problems

                      • Risk factors: History of lung or breathing problems

                        Though rare, people who took leflunomide (Arava) have developed interstitial lung disease (ILD), or scarring of the lung tissue. This lung problem can occur at any time during treatment and it can sometimes be life-threatening. Call your rheumatologist right away if you have symptoms of ILD, like cough or trouble breathing. You might need to go through a special process of taking certain medications to get rid of leflunomide (Arava) from the body quickly to help prevent further lung damage.

                        risk-warning

                        High blood pressure

                        Leflunomide (Arava) might raise your blood pressure. Your rheumatologist will check your blood pressure before you start treatment. The care team will also check your blood pressure at every follow-up visit while you're taking leflunomide (Arava). Let your care team know if you notice that your blood pressure is higher than what it was before you started leflunomide (Arava).

                        risk-warning

                        Slow removal of leflunomide (Arava) from your body

                        After you stop taking leflunomide (Arava), it can take up to two years for your body to completely get rid of the medication. This is important to consider if you're planning on becoming pregnant or have unwanted or serious side effects. Your rheumatologist might prescribe cholestyramine (Prevalite) or activated charcoal for you to take for 11 days to help speed up the process of removing leflunomide (Arava) from your body.

                        dosage

                        Leflunomide (Arava) dosage forms

                        The average cost for 30 tablets of 20mg of Leflunomide (Arava) is $22.00 with a free GoodRx coupon. This is 88.17% off the average retail price of $185.99.
                        tablet
                        Tablet
                        DosageQuantityPrice as low asPrice per unit
                        10mg30 tablets$22.00$0.73
                        20mg30 tablets$22.00$0.73

                        Typical dosing for Leflunomide (Arava)

                        Your rheumatologist might not prescribe the loading dose for you at the beginning of treatment if you're at high risk for serious side effects from the medication (e.g., liver problems, low blood cell count). In this case, you'll start off and continue with the maintenance dose.

                        interactions

                        Interactions between Leflunomide (Arava) and other drugs

                        Leflunomide (Arava) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Leflunomide (Arava). Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        drug-cost

                        How much does Leflunomide (Arava) cost?

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                        contraindications-icon

                        Leflunomide (Arava) contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Leflunomide (Arava) will not be safe for you to take.
                        alternatives

                        What are alternatives to Leflunomide (Arava)?

                        There are a number of medications that your doctor can prescribe in place of Leflunomide (Arava). Compare a few possible alternatives below.
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                        Sulfasalazine (Azulfidine)
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                        • Ulcerative colitis (UC) - immediate-release and delayed release tablets

                        • Rheumatoid arthritis (RA) - delayed-release tablets only

                        • Polyarticular juvenile rheumatoid arthritis - delayed-release tablets only

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                        images

                        Leflunomide (Arava) images

                        White Round Gg And 994 - Leflunomide 20mg Tablet
                        This medicine is White, Round Tablet Imprinted With "994" And "Gg".White Round Gg And 994 - Leflunomide 20mg Tablet
                        White Triangle Hp44 - Leflunomide 20mg Tablet
                        This medicine is White, Triangle Tablet Imprinted With "Hp44".White Triangle Hp44 - Leflunomide 20mg Tablet
                        White Triangle Apo And Le 20 - Leflunomide 20mg Tablet
                        This medicine is White, Triangle Tablet Imprinted With "Le 20" And "Apo".White Triangle Apo And Le 20 - Leflunomide 20mg Tablet
                        White Triangle Hp44 - Leflunomide 20mg Tablet
                        This medicine is White, Triangle Tablet Imprinted With "Hp44".White Triangle Hp44 - Leflunomide 20mg Tablet
                        Yellow Triangle L116 - Leflunomide 20mg Tablet
                        This medicine is Yellow, Triangle Tablet Imprinted With "L116".Yellow Triangle L116 - Leflunomide 20mg Tablet
                        White Triangle 58 And 11 - Leflunomide 20mg Tablet
                        This medicine is White, Triangle Tablet Imprinted With "11" And "58".White Triangle 58 And 11 - Leflunomide 20mg Tablet
                        Yellow Round A5 And L - Leflunomide 20mg Tablet
                        This medicine is Yellow, Round Tablet Imprinted With "A5" And "L".Yellow Round A5 And L - Leflunomide 20mg Tablet

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                        References

                        Best studies we found

                        American Academy of Dermatology Association. (n.d.). Hair loss: Tips for managing.

                        American College of Rheumatology. (n.d.). Rheumatologist.

                        Apotex Corp. (2023). Leflunomide tablet [package insert]. DailyMed.

                        View All References (4)

                        National Heart, Lung, and Blood Institute. (2022). Thrombocytopenia.

                        Osiri, M., et al. (2003). Leflunomide for the treatment of rheumatoid arthritis. Cochrane Database of Systematic Reviews.

                        Padda, I. S., et al. (2023). Leflunomide. StatPearls.

                        Strand, V., et al. (1999). Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Archives of Internal Medicine.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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