provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content

Lazanda

fentanyl
Used for Pain
Used for Pain

Lazanda (fentanyl) is a strong pain medication used to treat breakthrough cancer pain in people who already take around-the-clock opioid pain medications. It's a nasal spray that can be used by adults over the age of 18, but it requires special monitoring because of the risk of abuse, addiction, and overdose.

Last reviewed on January 24, 2022
Lazanda (fentanyl) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Lazanda (fentanyl)?

What is Lazanda (fentanyl) used for?

  • Breakthrough cancer pain in adults 18 years and older

How Lazanda (fentanyl) works

Lazanda (fentanyl) belongs to a group of pain medications, known as opioids. It works directly on opioid receptors in your brain to relieve pain.

Are you looking for information on fentanyl (Duragesic) patch, fentanyl (Fentora) tablets, Subsys (fentanyl) oral spray, or fentanyl (Actiq) lozenge instead?

Drug Facts

Common BrandsLazanda
Drug ClassOpioid
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$00
GoodRx discount
$1623.66
See prices
warings-icon

What are the risks and warnings for Lazanda (fentanyl)?

Lazanda (fentanyl) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Life-threatening slowed breathing (respiratory depression)

  • Risk factors: First 1 to 3 days of starting Lazanda (fentanyl) | Dose changes | High doses | Switching between fentanyl-containing medications | Opioid-intolerance | Accidental overdose | Children | Age 65 years or older | Severe lung conditions | History of sleep apnea | Taking other medications that cause respiratory depression

    Lazanda (fentanyl) can cause serious,
    life-threatening slowed breathing (respiratory depression) and death, even at normal doses. Your risk is greatest during the first 24 to 72 hours of starting Lazanda (fentanyl) and after your dose is raised. If you're opioid-intolerant, meaning you aren't taking opioids around-the-clock, don't take Lazanda (fentanyl).

    For your safety, use Lazanda (fentanyl) exactly as prescribed by your healthcare provider, and don't adjust your dose or switch between products without discussing with your provider first. Lazanda (fentanyl) is NOT equal to other forms of fentanyl, such as the patch, pills, or lozenge. Don't convert, switch, or substitute Lazanda (fentanyl) with any other fentanyl-containing medications without proper guidance from your healthcare provider. Make sure to discuss your entire medical history with your provider, since some conditions put you at a higher risk for respiratory depression.

    Accidental ingestion of even one dose, especially by children, can lead to severe breathing problems and death. Respiratory depression is a medical emergency that must be managed and treated right away. Alcohol and other medications, like benzodiazepines, sedatives, anxiety medications, and certain muscle relaxants, can slow down your breathing even more and you should avoid taking them together with Lazanda (fentanyl). If you have shortness of breath, wheezing, slowed breathing, tiredness or sleepiness during the day, anxiety, or confusion, call for emergency medical help right away.

    risk-warning

    Accidental overdose

    • Risk factors: Children | Using more Lazanda (fentanyl) than prescribed

      Overdose can happen at recommended doses of Lazanda (fentanyl), or if it's accidentally taken by a child or a loved one. Accidental ingestion of even one dose in a child can cause overdose and death. It can also happen if you take higher doses or take the medication more often than prescribed. If you live in a home with children or if children frequently visit your home, store both used and unused medication in a secure place. For questions about proper storage or disposal of Lazanda (fentanyl), refer to the medication guide that came with your medication or ask your pharmacist.

      Symptoms of an overdose include slowed breathing, sleepiness, muscle weakness, small pupils, cold or clammy skin, abnormal snoring, low blood pressure, slow heart rate, or unresponsiveness. If you, your child, or anyone around you accidentally overdoses on Lazanda (fentanyl), get emergency medical help right away. If you're at a high risk for overdose, have a history of opioid overdose, or live with children or other family members at high risk, your provider might prescribe naloxone (Narcan). Naloxone (Narcan) can be used in emergency situations for Lazanda (fentanyl) overdose. It's important for you and your caregiver to know how to use naloxone (Narcan) in case an accidental overdose happens. Even if you use naloxone (Narcan) for an overdose, you'll still have to call for emergency medical help because it's effects are temporary and only last for a few minutes.

      risk-warning

      Interactions with other medications

      Using Lazanda (fentanyl) with certain medications or suddenly stopping some medications can raise or lower levels of Lazanda (fentanyl) in your body. For example, taking erythromycin (Ery-Tab), ketoconazole, or ritonavir (Norvir) raises Lazanda (fentanyl) levels, leading to greater side effects, such as slowed breathing. Other medications like phenytoin (Dilantin), carbamazepine (Tegretol), or rifampin (Rifadin) can lower Lazanda (fentanyl) levels in your body, leading to withdrawal symptoms or lessened pain relief. In these situations, your provider might need to adjust your medications or dosage. If you start or stop any medications, ask your pharmacist or healthcare provider if it's safe to continue using Lazanda (fentanyl).

      risk-warning

      Slowed brain function and lowered alertness

      • Risk factors: Age 65 years or older | Alcohol use | Taking other medications that make you less alert | High doses

        Using Lazanda (fentanyl) with alcohol or other medications, like benzodiazepines, sleep medications, antipsychotics, muscle relaxers, or other opioids, can slow down brain activity and lead to severe sleepiness, slowed breathing, coma, and even death. If you currently take or start taking any of these medications, work with your healthcare provider to take the lowest dose for the shortest amount of time. Because of the risk of excessive drowsiness, make sure you know how this medication affects you before driving a car or doing activities that require concentration. For your safety, let your provider know if you have a history of substance abuse. Call for emergency medical help right away if you experience severe sleepiness, dizziness, low heart rate, slowed breathing, muscle weakness, headache, slurred speech, blurred vision, or confusion.

        risk-warning

        Potential for addiction, abuse, and misuse

        • Risk factors: Personal or family history of substance or alcohol abuse | History of mental health conditions | Using more Lazanda (fentanyl) than prescribed | Long-term use of Lazanda (fentanyl) | Improper storage or disposal of Lazanda (fentanyl)

          Using Lazanda (fentanyl) can lead to abuse, misuse (using it for reasons other than prescribed), or addiction, even if you use it at the recommended dose. This can cause serious problems, such as overdose and death. Your risk is greater if you have a history of substance or alcohol abuse or mental health conditions, such as depression. To lower this risk, your healthcare provider will prescribe the lowest amount of Lazanda (fentanyl) that's necessary for you for the shortest period of time possible. It's important to properly store and dispose of used and unused medication to prevent it from coming into contact with anyone else.

          Because of the risk of abuse, misuse, addiction, and overdose, the U.S. Food and Drug Administration (FDA) requires this medication to be under a restricted program called the Transmucosal Immediate Release Fentanyl Risk Evaluation and Mitigation Strategy (TIRF REMS). This means that Lazanda (fentanyl) is only available at certified pharmacies, and healthcare providers must complete special training before prescribing this medication. Under this program, your provider or pharmacist is required to provide you with a medication guide and talk to you about the proper use, serious risks, and appropriate storage and disposal of this medication in order to keep you and your loved ones safe. It's important that you read the medication guide every time to familiarize yourself with safe use of this medication. To learn more about the TIRF REMS program or for a list of certified pharmacies, visit the website or call 1-866-822-1483.

          risk-warning

          Withdrawal in newborn babies

          • Risk factors: Long-term use of Lazanda (fentanyl) during pregnancy

            Long-term use of Lazanda (fentanyl) during pregnancy can cause your unborn baby to become dependent on opioids the same way that you can. Once your baby is born, they can experience withdrawal symptoms just like if you were to stop the medication suddenly. Withdrawal symptoms in your newborn can include high-pitched crying, poor feeding and sucking behavior, trembling, irritability, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare provider know if you've used Lazanda (fentanyl) during pregnancy or if you notice these symptoms in your baby.

            risk-warning

            Serotonin syndrome

            • Risk factors: Using Lazanda (fentanyl) with serotonergic medications

              Using Lazanda (fentanyl) with other medications that raise serotonin levels in your brain, known as serotonergic medications, can cause a life-threatening condition called serotonin syndrome. Some examples of serotonergic medications include fluoxetine (Prozac), duloxetine (Cymbalta), amitriptyline (Elavil), sumatriptan (Imitrex), and trazodone (Desyrel). Serotonin syndrome generally occurs within a few hours or a few days of combining these medications, but might occur later. Let your healthcare provider or pharmacist know if you start a new medication to make sure it's safe to combine with Lazanda (fentanyl). Call for emergency medical help right away and stop using Lazanda (fentanyl) if you experience nausea, vomiting, diarrhea, fever, agitation, hallucinations (seeing things that aren't there), shivering, restlessness, sweating, fast heart rate, or stiff muscles.

              risk-warning

              Low hormone levels (adrenal insufficiency)

              • Risk factors: Using opioids for greater than 1 month | History of low cortisol levels

                Using opioids like Lazanda (fentanyl), especially for longer than 1 month, can lead to low levels of cortisol hormone (adrenal insufficiency). Cortisol helps control your mood, stress, blood pressure, and blood sugar levels. If you have symptoms such as nausea, vomiting, loss of appetite, tiredness, weakness, dizziness, or low blood pressure, let your healthcare provider know so that tests can be performed. If your cortisol levels are too low, your provider will treat you with corticosteroids and you might slowly be weaned off of Lazanda (fentanyl) or switched to another medication if necessary.

                risk-warning

                Low blood pressure and heart rate

                • Risk factors: Age 65 years or older | Taking other medications that lower blood pressure | Dehydration | History of low blood pressure | Taking certain antipsychotics | Starting Lazanda (fentanyl) | Dose adjustments | History of slow heart rate | Heart problems

                  Lazanda (fentanyl) can cause severe low blood pressure, including a drop in blood pressure when you stand from a sitting or lying position. This can lead to dizziness and fainting. Your risk is greater if you take medications for high blood pressure or if you take certain antipsychotics, known as phenothiazines. Be careful as you stand up after sitting for an extended period of time and make sure to sit back down if you feel faint or dizzy. The chances of low blood pressure are higher when you first start using Lazanda (fentanyl) or with dose changes. Lazanda (fentanyl) can also cause slowed heart rate. Make sure to let your provider know if you have a history of heart problems, like abnormal heart rate (arrhythmias). If dizziness or lightheadedness doesn't go away, talk to your healthcare provider.

                  risk-warning

                  Seizures

                  • Risk factors: History of seizures | Taking other medications or having health conditions that raise your risk of seizures

                    Lazanda (fentanyl) can raise your risk of seizures if you have a history of seizures. If your seizures have worsened or become harder to control after starting Lazanda (fentanyl), let your healthcare provider know right away.

                    basics-icon

                    What are the side effects of Lazanda (fentanyl)?

                    The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

                    Common Side Effects

                    • Vomiting (7-13%)
                    • Constipation (1-10%)
                    • Nausea (4-9%)
                    • Fever (5-7%)

                    Other Side Effects

                    • Stomach pain
                    • Dry mouth
                    • Loss of appetite
                    • Dizziness
                    • Sleepiness
                    • Headache
                    • Changes in taste
                    • Nosebleed
                    • Stuffy nose

                    Serious Side Effects

                    Contact your healthcare provider immediately if you experience any of the following.
                    • Overdose: not responding to sound or touch, slowed breathing, sleepiness, muscle weakness, small pupils, cold or clammy skin, abnormal snoring, low blood pressure, slow heart rate, unresponsiveness, coma
                    • Serious allergic reaction: hives, shortness of breath, chest tightness, swelling of lips, tongue, face, or eyes
                    • Slowed breathing
                    • Withdrawal in newborn babies: irritability, overactivity, abnormal sleeping pattern, excessive or high-pitched crying, body shaking (tremor), vomiting, diarrhea, unable to gain weight, breathing problems, fever, sweating, seizures
                    • Adrenal insufficiency (low cortisol levels): nausea, vomiting, stomach pain, low appetite, tiredness, weakness, dizziness, low blood pressure
                    • Withdrawal: restlessness, runny nose, yawning, sweating, chills, widened pupils, irritability, anxiety, suicidal thoughts

                    Source: DailyMed

                    The following side effects have also been reported

                    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

                    Check with your doctor immediately if any of the following side effects occur:

                    More common

                    Fever

                    Less common

                    Abdominal or stomach pain

                    anxiety

                    black, tarry stools

                    bladder pain

                    bloating or swelling of the face, arms, hands, lower legs, or feet

                    bloody nose

                    bloody or cloudy urine

                    blurred vision

                    body aches or pain

                    chest pain

                    chills

                    clay-colored stools

                    confusion

                    cough

                    cough producing mucus

                    dark urine

                    decreased urination

                    decreased weight

                    difficult or labored breathing

                    difficult, burning, or painful urination

                    difficulty with breathing

                    dizziness or lightheadedness

                    dry mouth

                    ear congestion

                    fainting

                    frequent urge to urinate

                    headache

                    hives

                    hoarseness

                    increase in heart rate

                    increased sweating

                    irritation

                    itching

                    joint pain, stiffness, or swelling

                    loss of appetite

                    loss of voice

                    lower back or side pain

                    nausea

                    nervousness

                    pain, redness, or swelling in the arm or leg

                    pale skin

                    pounding in the ears

                    rapid breathing

                    rapid weight gain

                    rash

                    redness of the skin

                    runny or stuffy nose

                    shortness of breath

                    slow or fast heartbeat

                    sneezing

                    sore throat

                    sudden shortness of breath or troubled breathing

                    sunken eyes

                    swelling of the eyelids, face, lips, hands, or feet

                    thirst

                    tightness in the chest

                    tingling of the hands or feet

                    troubled breathing or swallowing

                    troubled breathing with exertion

                    ulcers, sores, or white spots in the mouth

                    unpleasant breath odor

                    unusual bleeding or bruising

                    unusual tiredness or weakness

                    unusual weight gain or loss

                    vomiting of blood

                    wrinkled skin

                    yellow eyes or skin

                    Incidence not known

                    Irregular, fast or slow, or shallow breathing

                    pale or blue lips, fingernails, or skin

                    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

                    More common

                    Difficulty having a bowel movement (stool)

                    sleepiness or unusual drowsiness

                    vomiting

                    Less common

                    Acid or sour stomach

                    back pain

                    belching

                    burning feeling in the chest or stomach

                    change in taste

                    confusion about identity, place, and time

                    decreased appetite

                    depression

                    diarrhea

                    difficulty with moving

                    drooping upper eyelids

                    dry eyes

                    flushed, dry skin

                    fruit-like breath odor

                    heartburn

                    hyperventilation

                    increased hunger

                    increased thirst

                    increased urination

                    indigestion

                    irregular heartbeats

                    irritability

                    irritation or soreness of the mouth

                    lack or loss of strength

                    loss of taste

                    muscle aches

                    muscle pain or stiffness

                    pain in the arms or legs

                    pain in the rectum

                    restlessness

                    shaking

                    sleeplessness

                    stomach discomfort or upset

                    stomach bloating

                    sweating

                    tenderness in the stomach area

                    trouble with sleeping

                    troubled breathing

                    unable to sleep

                    unexplained weight loss

                    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

                    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

                    pros-and-cons

                    Pros and cons of Lazanda (fentanyl)

                    thumbs-up

                    Pros

                    Available in multiple dosage strengths

                    Works in about 7 minutes to relieve breakthrough cancer pain

                    Good alternative if you have trouble swallowing pills

                    Comes with a child-resistant container and pouch for safe storage and disposal

                    thumbs-down

                    Cons

                    Brand only, so it might be expensive

                    Can only be used if you already take opioids around-the-clock (opioid-tolerance)

                    Has undesirable side effects, such as nausea, vomiting, fever, and constipation

                    Not for short-term pain, such as dental pain, headaches or migraines, or pain after surgery

                    Can't be used in children younger than 18 years old

                    pharmacist-tips

                    Pharmacist tips for Lazanda (fentanyl)

                    pharmacist
                    • Before using Lazanda (fentanyl), refer to the instructions and make sure you know how to prepare and use it.

                      • You'll need to prime (or prepare) the bottle the first time you use Lazanda (fentanyl) so that you get a proper dose. To prime your bottle, remove the cap from the nozzle (tip) and place the tip into the opening of the disposal pouch. A new and unused bottle will show 2 thin red lines in the white plastic top ("window") of the bottle. Press and release the grips 4 times until you see a green bar in the window. Once the green bar appears, your bottle is primed and ready to use.

                        • If you don't use Lazanda (fentanyl) for more than 5 days, you'll need to re-prime your bottle by spraying once into the pouch.

                          • To use Lazanda (fentanyl), remove the cap from the tip. Sit with your head upright and hold the spray bottle with your thumb on the bottom of the bottle and your first and middle fingers on the grips around the tip. Place the tip into your nose (about ½ inch) and point the tip towards the bridge of your nose by slightly tilting your bottle. Use one finger to close your other nostril. Press down on the grip and breathe in through your nose and out through your mouth one time after spraying. Don't sniff.

                            • It's okay if you don't feel the spray going into your nose. You'll hear a "click" sound and the number in the window of the bottle will go up by 1, which tells you that you received your dose.

                              • If you have a runny nose or feel like blowing your nose, do so before your dose of Lazanda (fentanyl). Avoid blowing your nose for at least 30 minutes after your dose because you might accidentally remove medication from your nose, leading to a lower dose.

                                • If your provider prescribed multiple sprays, be sure to alternate nostrils for each dose. This will ensure that you get the proper amount of medication. Continue sitting down for at least 1 minute after each spray.

                                  • Each bottle of Lazanda (fentanyl) contains 8 sprays. The counting window will show a red "8" when your bottle no longer has any doses left. Once you've used 8 sprays or it's been longer than 60 days since you first used your bottle, throw the bottle away and use a new one.

                                    • If there's any medication left in the bottle, squeeze it out into the disposal pouch before throwing the bottle away. This ensures that no one, especially children, can come into contact with the medication. If you don't have an empty pouch, call 1-844-452-9263 to request one in the mail.

                                      • Place the empty spray bottle and the sealed pouch into the child-resistant container and throw it away in a trash can. Wash your hands with soap and water after handling the medication.

                                        • Lazanda (fentanyl) can cause excessive sleepiness, dizziness, and lightheadedness. Don't drive, use any heavy machinery, or perform any activities that require you to be alert until you know how the medication affects you.

                                          • Talk to your pharmacist or healthcare provider about naloxone (Narcan), which is a medication that can be used in emergency situations for accidental overdose of Lazanda (fentanyl). Make sure to tell your family and close friends where you keep your naloxone (Narcan) in the event of an emergency, and read the patient information material before an emergency situation occurs. Symptoms of an overdose include slowed breathing, sleepiness, muscle weakness, small pupils, cold or clammy skin, abnormal snoring, low blood pressure, slow heart rate, or unresponsiveness. If you use naloxone (Narcan) for an overdose situation, you should still call for emergency medical help because its effects are temporary.

                                            • Don't lower your dose or stop taking Lazanda (fentanyl) suddenly without talking to your healthcare provider. Doing so might lead to withdrawal symptoms, including nausea, sweating, yawning, and trouble sleeping.

                                              • Store Lazanda (fentanyl) at room temperature in a secure place protected from light and out of reach from children, pets, and guests at all times. Your medication will come with a child-resistant container where the spray bottle should be stored after each use. Lazanda (fentanyl) has a risk of life-threatening overdose, especially in children. If your child accidentally comes into contact with Lazanda (fentanyl), get emergency medical help right away.

                                                faqs

                                                Frequently asked questions about Lazanda (fentanyl)

                                                What does "opioid-tolerant" mean?
                                                You're considered "opioid-tolerant" if you take a specific amount of opioid pain medications daily for 1 week or longer. This includes at least 60 mg of morphine per day, 25 mcg of transdermal fentanyl (patch) per hour, 30 mg of oxycodone per day, or a dose of another opioid that's considered equivalent. If you don't take opioids around-the-clock or aren't considered opioid tolerant, you can't use Lazanda (fentanyl) because of the high risk of life-threatening breathing problems and death, even at low doses. Your healthcare provider and pharmacist have to confirm your opioid tolerance before writing or filling your prescription.
                                                What is the TIRF REMS program and why is Lazanda (fentanyl) under this program?
                                                Lazanda (fentanyl) is a controlled medication that has special requirements because of it's risk of addiction, abuse, misuse, and overdose. The TIRF REMS, or Transmucosal Immediate Release Fentanyl (TIRF) Risk Evaluation and Mitigation Strategy, is a program that monitors the safe use of Lazanda (fentanyl). Under this program, healthcare providers have to complete special training and documentation in order to write a prescription for Lazanda (fentanyl), and pharmacies must be certified to dispense the medication. To learn more about the TIRF REMS program or to find a list of certified pharmacies, visit the website or call 1-866-822-1483.
                                                How often can I use Lazanda (fentanyl) to treat my breakthrough cancer pain?
                                                Work with your healthcare provider to understand what dose is safe for you, and how to adjust your dose. You'll typically start with using one spray (100 mcg) in one nostril for the first episode of breakthrough pain. If this dose relieves your pain within 30 minutes, use the same dose for your next episode of breakthrough pain. Your provider will give you a titration schedule to follow closely. You must wait at least 2 hours before treating another episode of breakthrough pain. Ask your pharmacist or provider if you have further questions about dosing. Don't use Lazanda (fentanyl) to treat more than 4 episodes of breakthrough pain per day. If you're having more than 4 episodes daily, speak with your provider because you might require a higher dose of your scheduled pain medications.
                                                Is Lazanda (fentanyl) equivalent to other medications that contain fentanyl?
                                                No. Dosing for Lazanda (fentanyl) and other forms of fentanyl (such as the patch, pills, or lozenge) is NOT equivalent. Don't switch between Lazanda (fentanyl) and other medications that contain fentanyl before discussing with your healthcare provider. Taking too much fentanyl can lead to life-threatening overdose, breathing problems, low blood pressure, and dizziness. Taking too little fentanyl might not allow you to have the same degree of pain relief. Your starting dose of Lazanda (fentanyl) might not be the same as your dose of other forms of fentanyl. If you're unsure about your pain medications or have questions about your dose, ask your pharmacist or provider for further guidance.
                                                Is it safe to use Lazanda (fentanyl) while pregnant?
                                                Lazanda (fentanyl) is NOT recommended during pregnancy or right before labor and delivery because it can cause harm to your unborn baby and prolong your labor. Long-term use of Lazanda (fentanyl) during pregnancy can cause withdrawal symptoms in your newborn baby, including vomiting, diarrhea, high-pitched crying, irritability, breathing problems, fever, or seizures. This condition can become life-threatening if it isn't managed and treated right away. If you're pregnant or plan on becoming pregnant, discuss the risks and benefits of using Lazanda (fentanyl) with your healthcare provider because it can also affect your ability to become pregnant.
                                                GoodRxEducationalIcon

                                                How to save using GoodRx

                                                Compare Prices
                                                1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
                                                Select your free coupon
                                                2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
                                                Show coupon to your pharmacist
                                                3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
                                                Get free couponLearn more
                                                dosage

                                                Lazanda (fentanyl) dosage forms

                                                Typical dosing for Lazanda (fentanyl)

                                                Your provider will work with you to prescribe the right dose of Lazanda (fentanyl) for your individual needs. It's recommended to use the lowest dose possible for the shortest duration of time to manage your pain.

                                                The typical starting dose is one spray (100 mcg) in one nostril for one episode of breakthrough pain.

                                                interactions

                                                Interactions between Lazanda (fentanyl) and other drugs

                                                Lazanda (fentanyl) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Lazanda (fentanyl). Please note that only the generic name of each medication is listed below.

                                                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                                drug-cost

                                                How much does Lazanda (fentanyl) cost?

                                                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                                                contraindications-icon

                                                Lazanda (fentanyl) contraindications

                                                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Lazanda (fentanyl) will not be safe for you to take.
                                                • Not taking around-the-clock opioids (opioid non-tolerance)

                                                • Short-term pain, such as headache or migraine, dental pain, or pain after surgery

                                                • Slowed breathing (respiratory depression)

                                                • Severe asthma

                                                • Stomach or intestinal blockage (paralytic ileus)

                                                alternatives

                                                What are alternatives to Lazanda (fentanyl)?

                                                There are a number of medications that your doctor can prescribe in place of Lazanda (fentanyl). Compare a few possible alternatives below.
                                                Lazanda (fentanyl)
                                                Used for:
                                                • Breakthrough cancer pain in adults 18 years and older

                                                $1623.66 Lowest GoodRx priceView Prices
                                                Used for:
                                                • Breakthrough cancer pain in adults 18 years and older

                                                Used for:
                                                • Breakthrough cancer pain in people 16 years and older

                                                $725.00 Lowest GoodRx priceView Prices

                                                Get savings updates for Lazanda (fentanyl)

                                                Receive price alerts, news, and other messages from GoodRx about Lazanda (fentanyl) and other healthcare topics and relevant savings offers.

                                                By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                                                Browse medications

                                                View All

                                                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.