fentanyl citrate

Fentanyl (Actiq) can cause serious,
life-threatening slowed breathing (respiratory depression) and death, even at normal doses. Your risk is greatest during the first 24 to 72 hours of starting fentanyl (Actiq) and after your dose is raised. If you're opioid-intolerant, meaning you aren't taking opioids around-the-clock, don't take fentanyl (Actiq).

Overdose can happen at recommended doses of fentanyl (Actiq), or if it's accidentally taken by a child or a loved one. Accidental ingestion of even one dose in a child can cause overdose and death. It can also happen if you take higher doses or take the medication more often than prescribed. If you live in a home with children or if children frequently visit your home, store both used and unused medication in a secure place. For questions about proper storage or disposal of fentanyl (Actiq), refer to the medication guide that came with your medication or ask your pharmacist.

Using fentanyl (Actiq) with certain medications or suddenly stopping some medications can raise or lower levels of fentanyl (Actiq) in your body. For example, taking erythromycin (Ery-Tab), ketoconazole, or ritonavir (Norvir) raises fentanyl (Actiq) levels, leading to greater side effects, such as slowed breathing. Other medications like phenytoin (Dilantin), carbamazepine (Tegretol), or rifampin (Rifadin) can lower fentanyl (Actiq) levels in your body, leading to withdrawal symptoms or lessened pain relief. In these situations, your provider might need to adjust your medications or dosage. If you start or stop any medications, ask your pharmacist or healthcare provider if it's safe to continue using fentanyl (Actiq).

Using fentanyl (Actiq) with alcohol or other medications, like benzodiazepines, sleep medications, antipsychotics, muscle relaxers, or other opioids, can slow down brain activity and lead to severe sleepiness, slowed breathing, coma, and even death. If you currently take or start taking any of these medications, work with your healthcare provider to take the lowest dose for the shortest amount of time. Because of the risk of excessive drowsiness, make sure you know how this medication affects you before driving a car or doing activities that require concentration. For your safety, let your provider know if you have a history of substance abuse. Call for emergency medical help right away if you experience severe sleepiness, dizziness, low heart rate, slowed breathing, muscle weakness, headache, slurred speech, blurred vision, or confusion.

Using fentanyl (Actiq) can lead to abuse, misuse (using it for reasons other than prescribed), or addiction, even if you use it at the recommended dose. This can cause serious problems, such as overdose and death. Your risk is greater if you have a history of substance or alcohol abuse or mental health conditions, such as depression. To lower this risk, your healthcare provider will prescribe the lowest amount of fentanyl (Actiq) that's necessary for you for the shortest period of time possible. It's also important to properly store and dispose of used and unused medication to prevent it from coming into contact with anyone else.

Long-term use of fentanyl (Actiq) during pregnancy can cause your unborn baby to become dependent on opioids the same way that you can. Once your baby is born, they can experience withdrawal symptoms just like if you were to stop the medication suddenly. Withdrawal symptoms in your newborn can include high-pitched crying, poor feeding and sucking behavior, trembling, irritability, abnormal sleep patterns, and seizures. This condition is called neonatal opioid withdrawal syndrome and can be life-threatening if not recognized and treated in time. Let your healthcare provider know if you've used fentanyl (Actiq) during pregnancy or if you notice these symptoms in your baby.

Using fentanyl (Actiq) with other medications that raise serotonin levels in your brain, known as serotonergic medications, can cause a life-threatening condition called serotonin syndrome. Some examples of serotonergic medications include fluoxetine (Prozac), duloxetine (Cymbalta), amitriptyline (Elavil), sumatriptan (Imitrex), monoamine oxidase inhibitors (MAOIs), and trazodone (Desyrel). Serotonin syndrome generally occurs within a few hours or a few days of combining these medications, but might occur later. Let your healthcare provider or pharmacist know if you start a new medication to make sure it's safe to combine with fentanyl (Actiq). Call for emergency medical help right away and stop using fentanyl (Actiq) if you experience nausea, vomiting, diarrhea, fever, agitation, hallucinations (seeing things that aren't there), shivering, restlessness, sweating, fast heart rate, or stiff muscles.

Using opioids like fentanyl (Actiq), especially for longer than 1 month, can lead to low levels of cortisol hormone (adrenal insufficiency). Cortisol helps control your mood, stress, blood pressure, and blood sugar levels. If you have symptoms such as nausea, vomiting, loss of appetite, tiredness, weakness, or dizziness, let your healthcare provider know so that tests can be performed. If your cortisol levels are too low, your provider will treat you with corticosteroids and you might slowly be weaned off of fentanyl (Actiq) or switched to another medication if necessary.

Fentanyl (Actiq) can cause severe low blood pressure, including a drop in blood pressure when you stand from a sitting or lying position. This can lead to dizziness and fainting. Your risk is greater if you take medications for high blood pressure or if you take certain antipsychotics, known as phenothiazines. Be careful as you stand up after sitting for an extended period of time and make sure to sit back down if you feel faint or dizzy. The chances of low blood pressure are higher when you first start using fentanyl (Actiq) or with dose changes. Fentanyl (Actiq) can also cause slowed heart rate. Make sure to let your provider know if you have a history of heart problems, like abnormal heart rate (arrhythmias). If dizziness or lightheadedness doesn't go away, talk to your healthcare provider.