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Efudex

Efudex Side Effects

Robert Chad Hakim, PharmD, BCCCPConnie Zheng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Connie Zheng, PharmD
Last reviewed on March 14, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Crusting of the skin
  • Stinging or burning feeling of the skin
  • Itchiness
  • Soreness on the skin
  • Scarring

Less Common Side Effects

  • Darkening of skin color
  • Skin tenderness
  • Open sores on skin
  • Rash
  • Swelling on the skin
  • Blistering

Efudex serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Rare toxicity reaction: Stomach pains, bloody diarrhea, vomiting, fever, chills, skin rash, painful sores in the mouth.
When do Efudex possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Skin redness
Crusting of the skin
Stinging or burning
Itching

Source: DailyMed

The following Efudex side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Redness and swelling of normal skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning feeling where medicine is applied

increased sensitivity of skin to sunlight

itching

oozing

skin rash

soreness or tenderness of skin

Less common or rare

Darkening of skin

scaling

watery eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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