The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Hand-and-foot syndrome (up to 60%)
- Diarrhea (up to 55%)
- Nausea (up to 43%)
- Fatigue or tiredness (up to 42%%)
- Stomach pain (up to 35%)
- Vomiting (up to 27%)
- Open mouth sores (up to 25%)
Note: Side effects were reported by people who took [[EDITOR|DRUG_DISPLAY_NAME]] for colon or colorectal cancer.
Less Common Side Effects
- Constipation
- Change in taste
- Hair loss
- Dizziness
- Headache
- Fever
- Rash
- Swelling
- Pain
- Trouble catching your breath
- Eye irritation
Capecitabine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe diarrhea or blood in your stool
- Severe skin reactions: rash, blisters, peeling skin, painful swelling
- Heart problems: heart attack, chest pain, abnormal heart rhythm
Source: DailyMed
The following Capecitabine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Abdominal or stomach pain
loss of fingerprints
numbness, pain, tingling, or other unusual sensations in the palms of the hands or bottoms of the feet
pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
pain, redness, swelling, sores, or ulcers in your mouth or on your lips
unusual tiredness or weakness
vomiting
Less common or rare
Abdominal or stomach cramping or pain (severe)
agitation
back pain
bleeding and bruising
bleeding gums
blood in the urine or stools
bloody nose
bloody or black, tarry stools
blurred vision
burning, dry, or itching eyes
chills
clumsiness or unsteadiness
collapse
coma
confusion
convulsions
cough or hoarseness (accompanied by fever or chills)
cough producing mucus
coughing or spitting up blood
dark urine
decreased frequency or amount of urine
difficulty with breathing
difficulty with swallowing or pain in the back of throat or chest when swallowing
discharge from the eyes
drowsiness
excessive tearing
extra heartbeats
eye redness, irritation, or pain
fainting
fast or irregular heartbeat
fever or chills
flu-like symptoms
hallucinations
headache, sudden and severe
heavier menstrual periods
high fever
hot, red skin on the feet or legs
inability to speak
increased menstrual flow or vaginal bleeding
increased thirst
irritability
itching in the genital or other skin areas
lightheadedness
light-colored stools
loss of consciousness
lower back or side pain (accompanied by fever or chills)
muscle aches or cramps
nosebleeds
numbness or tingling in the hands, feet, or lips
painful or difficult urination (accompanied by fever or chills)
painful, swollen feet or legs
pain, tenderness, or swelling in the upper abdominal or stomach area
pale skin
paralysis
pinpoint red spots on the skin
problems with coordination
prolonged bleeding from cuts
rapid, shallow breathing
red or dark brown urine
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
scaling
seizures
severe constipation
skin rash or itching
slow or irregular heartbeat
slurred speech
sneezing, sore throat, or stuffy nose
sores, ulcers, or white spots on the lips or in the mouth
stiff neck
stomach bloating, burning, or cramping
swelling of the face, fingers, feet, or lower legs
swelling of the lymph nodes
swollen glands
temporary blindness
tiredness or weakness
trouble with speaking
troubled breathing or tightness in the chest
unexplained nosebleeds
unusual bleeding or bruising
unusual lump or swelling in the chest
vomiting blood or material that looks like coffee grounds
weakness in the arm or leg on one side of the body, sudden and severe
weight gain or loss
white patches in the mouth or throat or on the tongue
white patches with diaper rash
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
changes or discoloration in the fingernails or toenails
difficulty with moving
discouragement
headache
increased sensitivity of the skin to sunlight
pain and redness of the skin at the place of x-ray treatment
pain in the joints or limbs
red, sore eyes
sunken eyes
thirst
trouble sleeping
weakness
wrinkled skin
Rare
Bone pain
change in color of treated skin
difficulty with walking
discouragement
feeling of constant movement of self or surroundings
feeling sad or empty
full or bloated feeling or pressure in the stomach
general feeling of discomfort or illness
hot flushes
impaired balance
increased sweating
joint pain
lack of appetite
loss of interest or pleasure
muscle weakness
noisy breathing
pain in the rectum
pain, swelling, or redness in the joints
passing less gas
rough, scratchy sound to voice
sensation of spinning
shakiness in the legs, arms, hands, or feet
shivering
sores on the skin
swelling of abdominal or stomach area
tremor or shaking of the hands or feet
trouble concentrating
voice changes
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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