provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Pirfenidone Coupon - Pirfenidone 801mg tablet

pirfenidone

Generic Esbriet
Used for Idiopathic Pulmonary Fibrosis
Used for Idiopathic Pulmonary Fibrosis

Pirfenidone, also known by its brand name, Esbriet, is an antifibrotic medication used to treat idiopathic pulmonary fibrosis (IPF) in adults, a condition that causes scarring in the lungs. The dose starts low and is slowly raised, and it's taken by mouth three times per day with food. Common side effects include nausea, stomach pain, and skin rash. Because there have been some cases of liver injury from taking this medication, you'll need regular lab work to check your liver health. It's available in both brand-name and generic versions.

Last reviewed on October 28, 2024
basics-icon

What is Pirfenidone (Esbriet)?

What is Pirfenidone (Esbriet) used for?

How Pirfenidone (Esbriet) works

Pirfenidone (Esbriet) is an antifibrotic medication. It's not exactly known how the medication works, but it's thought to slow the worsening of IPF by reducing inflammation and scarring in the lungs.

Drug Facts

Common BrandsEsbriet
Drug ClassAntifibrotic agent
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$10407.93(save 96.49%)
GoodRx discount
$364.95
See prices
basics-icon

What are the side effects of Pirfenidone (Esbriet)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (36%)
  • Rash (30%)
  • Stomach pain or discomfort (24%)
  • Upper respiratory tract infection (27%)
  • Diarrhea (26%)
  • Tiredness (26%)
  • Headache (22%)
  • Reduced appetite (21%)
  • Indigestion (19%)
  • Dizziness (18%)
  • Vomiting (13%)

Other Side Effects

  • Heartburn
  • Sinus inflammation
  • Difficulty sleeping
  • Weight loss
  • Joint pain
  • General weakness
  • Skin sensitivity
  • Itchiness
  • Change in taste
  • Non-heart-related chest pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Liver damage: stomach bloating, yellowing of your skin or the whites of your eyes, dark urine, pain on the upper right area of your stomach
  • Serious skin reactions: hives, blisters, skin reddening or peeling, sores in the mouth

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Pirfenidone (Esbriet)

thumbs-up

Pros

Helps people with idiopathic pulmonary fibrosis (IPF) live longer

Can be used with other therapies to treat IPF

Capsule or tablet taken by mouth

thumbs-down

Cons

Need regular blood tests to check liver health

Needs to be taken 3 times a day

Stomach-related side effects (e.g., nausea, stomach pain, diarrhea) are common

pharmacist-tips

Pharmacist tips for Pirfenidone (Esbriet)

pharmacist
  • When first starting pirfenidone (Esbriet), you'll need to follow a specific dose schedule for the first and second week. Your prescriber might prescribe the starter blister card to help you get the dose right. If your pills all come in a bottle, make sure you know how to adjust the dose after each week.

    • If you stop taking pirfenidone (Esbriet) for at least 2 or more weeks, talk to your prescriber before restarting it. You'll need to restart it at a lower dose.

      • Take pirfenidone (Esbriet) with food three times per day (with breakfast, lunch, and dinner). Food helps prevent side effects like nausea and dizziness.

        • Pirfenidone (Esbriet) has been linked to liver injury, so you’ll need regular blood work to monitor your liver health while taking this medication.

          • Tell your care team about all the medications you're taking before starting pirfenidone (Esbriet), especially ciprofloxacin (Cipro) or fluvoxamine, as these can interact. Don't start any new medications while taking pirfenidone (Esbriet) without talking to your prescriber or pharmacist first.

            • Pirfenidone (Esbriet) can cause skin sensitivity to the sun. To protect your skin, make sure to wear sunscreen when going outside, wear long-sleeve clothing, and limit exposure to sunlight.

              faqs

              Frequently asked questions about Pirfenidone (Esbriet)

              Is pirfenidone (Esbriet) discontinued?
              No, pirfenidone (Esbriet) 267 mg and 801 mg pills are still available. There used to be a 534 mg pill as well, but this strength was discontinued. It's not known why this strength was discontinued, but it wasn't due to concerns related to safety or how well the medication works.
              Does pirfenidone (Esbriet) prolong life?
              Yes. Studies show people who take pirfenidone (Esbriet) can live longer compared to people who don't take the medication. Keep in mind that everyone responds differently to medications. Your prescriber will regularly monitor you during treatment to see how well you're doing.
              How long can you take pirfenidone (Esbriet)?
              Pirfenidone (Esbriet) is usually taken long term. Your prescriber will likely have you continue taking it as long as it shows signs of slowing your IPF progression and you aren’t experiencing significant side effects. Talk to your prescriber if you have questions about how long you should be taking this medication.
              Is pirfenidone (Esbriet) a steroid?
              No, pirfenidone (Esbriet) isn't a steroid; it's an antifibrotic medication. Both steroids and antifibrotic medications reduce lung inflammation, but they do so in different ways. Each medication has a different role to treat IPF. Pirfenidone (Esbriet) is usually taken long term to slow down the worsening of IPF, while steroids are used short-term to treat flare-ups.
              What happens if you stop taking pirfenidone (Esbriet)?
              While pirfenidone (Esbriet) doesn't cure IPF, it can at least prolong life. If you stop taking pirfenidone (Esbriet), your IPF might worsen, potentially impacting your life expectancy. Additionally, if you stop taking the medication for more than 14 days in a row, you’ll need to restart at a lower dose. Don’t stop taking pirfenidone (Esbriet) unless directed by your care team.
              What's the difference between pirfenidone (Esbriet) and Ofev (nintedanib)?
              Both pirfenidone (Esbriet) and Ofev (nintedanib) are used to slow the worsening of IPF, but they work in different ways. Ofev (nintedanib) can also be used to treat other types of lung problems. Studies show both pirfenidone (Esbriet) and Ofev (nintedanib) work just as well as each other to slow the worsening of IPF, but mainly differ in side effects. People taking pirfenidone (Esbriet) reported fatigue, weakness, and skin-related side effects whereas people taking Ofev (nintedanib) mainly had diarrhea. Speak with your prescriber if you have questions about how these medications compare.
              Can you drink alcohol with pirfenidone (Esbriet)?
              It's probably best to limit alcohol with pirfenidone (Esbriet) because this combination can raise your risk for liver damage. Speak to your prescriber if you have questions about alcohol and this medication.
              GoodRxEducationalIcon

              How to save using GoodRx

              Compare Prices
              1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
              Select your free coupon
              2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
              Show coupon to your pharmacist
              3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
              Get free couponLearn more
              warings-icon

              What are the risks and warnings for Pirfenidone (Esbriet)?

              Pirfenidone (Esbriet) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Liver injury

              Pirfenidone (Esbriet) can cause liver problems, which can be severe or life-threatening. Your prescriber will monitor your liver enzymes to check your liver health before you start pirfenidone (Esbriet). After that, they’ll check monthly for the first 6 months, then every 3 months, and as needed. High liver enzymes usually return to normal after you stop taking this medication or switch to a lower dose. If you notice severe nausea, vomiting, right-sided stomach pain, fatigue, low or no appetite, or yellowing of the skin or eyes, get medical help right away.

              risk-warning

              Sunlight sensitivity

              • Risk factors: Sunlight or tanning lamps | Taking other medications that make you sensitive to sunlight

                Pirfenidone (Esbriet) makes your skin more sensitive to the sun or ultraviolet (UV) light. This means you can get sunburns more easily than usual. This can happen even during the winter and on overcast days. To lower your risk, make sure to wear sunscreen (SPF 50 or higher) when going outside and wear long-sleeved clothing to protect your skin. Also it's generally best to limit your time in the sun.

                risk-warning

                Severe skin reactions

                Although very rare, there have been reports of pirfenidone (Esbriet) causing serious and life-threatening skin reactions, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS). If you notice changes in your skin, like rash, blisters, redness, or peeling, or if you experience fever, rash, and swollen lymph nodes, stop using pirfenidone (Esbriet) and get medical attention immediately. If you're confirmed to have one of these serious skin conditions, you'll need to permanently stop pirfenidone (Esbriet).

                risk-warning

                Stomach-related side effects

                Pirfenidone (Esbriet) commonly causes stomach-related side effects (e.g., nausea, stomach pain, diarrhea, indigestion), especially during the first 3 months of treatment. But they tend to go away after a while. Talk to your prescriber if these side effects don't improve.

                dosage

                Pirfenidone (Esbriet) dosage forms

                Typical dosing for Pirfenidone (Esbriet)

                • Days 1 through 7: The typical dose is 267 mg by mouth three times a day with food (at breakfast, lunch, and dinner).

                • Days 8 through 14: The typical dose is 534 mg by mouth three times a day with food (at breakfast, lunch, and dinner).

                • Days 15 and onward: The typical dose is 801 mg by mouth three times a day with food (at breakfast, lunch, and dinner).

                Your dose will differ depending on your liver labs and if you're taking medications that interact with pirfenidone (Esbriet).

                drug-cost

                How much does Pirfenidone (Esbriet) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                alternatives

                What are alternatives to Pirfenidone (Esbriet)?

                There are a number of medications that your doctor can prescribe in place of Pirfenidone (Esbriet). Compare a few possible alternatives below.
                images

                Pirfenidone (Esbriet) images

                Purple Oval 3611 And Teva - Pirfenidone 801mg Tablet
                This medicine is Purple, Oval Tablet Imprinted With "Teva" And "3611".Purple Oval 3611 And Teva - Pirfenidone 801mg Tablet
                Red Oval H And P 17 - Pirfenidone 801mg Tablet
                This medicine is Red, Oval Tablet Imprinted With "H" And "P 17".Red Oval H And P 17 - Pirfenidone 801mg Tablet
                Brown Oval Ac70 - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "Ac70".Brown Oval Ac70 - Pirfenidone 801mg Tablet
                Brown Oval 801 And Apo - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "801" And "Apo".Brown Oval 801 And Apo - Pirfenidone 801mg Tablet
                Brown Oval L And 750 - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "750" And "L".Brown Oval L And 750 - Pirfenidone 801mg Tablet
                Brown Oval 443 - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "443".Brown Oval 443 - Pirfenidone 801mg Tablet
                Brown Oval N870 - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "N870".Brown Oval N870 - Pirfenidone 801mg Tablet
                Brown Oval 443 - Pirfenidone 801mg Tablet
                This medicine is Brown, Oval Tablet Imprinted With "443".Brown Oval 443 - Pirfenidone 801mg Tablet

                Get savings updates for Pirfenidone (Esbriet)

                Receive price alerts, news, and other messages from GoodRx about Pirfenidone (Esbriet) and other healthcare topics and relevant savings offers.

                By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.

                References

                Best studies we found
                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                Was this page helpful?

                Browse medications

                View All

                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.