Compare
Pirfenidone vs. Ofev

Pirfenidone, also known by its brand name, Esbriet, is an antifibrotic medication used to treat idiopathic pulmonary fibrosis (IPF) in adults, a condition that causes scarring in the lungs. The dose starts low and is slowly raised, and it's taken by mouth three times per day with food. Common side effects include nausea, stomach pain, and skin rash. Because there have been some cases of liver injury from taking this medication, you'll need regular lab work to check your liver health. It's available in both brand-name and generic versions.

• Idiopathic pulmonary fibrosis (IPF) in adults

• Nausea (36%)
• Rash (30%)
• Stomach pain or discomfort (24%)
• Upper respiratory tract infection (27%)
• Diarrhea (26%)
• Tiredness (26%)
• Headache (22%)
• Reduced appetite (21%)
• Indigestion (19%)
• Dizziness (18%)
• Vomiting (13%)

• Liver injury
• Sunlight sensitivity
• Severe skin reactions
• Stomach-related side effects

Ofev (nintedanib) is a brand-name medication used to treat adults with certain types of interstitial lung disease (ILD), like idiopathic pulmonary fibrosis. It belongs to a group of medications called tyrosine kinase inhibitors, which work by slowing down the build up of scar tissue in the lungs. You typically take a dose by mouth twice a day with food to lower the chance of side side effects. Some common side effects include diarrhea, nausea, and stomach pain.

Ofev (nintedanib) treats certain types of interstitial lung disease (ILD):

• Idiopathic pulmonary fibrosis (IPF)
• Progressive fibrosing interstitial lung disease (PF-ILD)
• Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

IPF

• Diarrhea (62%)
• Nausea (24%)
• Stomach pain (15%)
• Rise in liver enzymes (14%)
• Vomiting (12%)
• Reduced appetite (11%)
• Weight loss (10%)

PF-ILD

• Diarrhea (67%)
• Nausea (29%)
• Vomiting (18%)
• Reduced appetite (15%)
• Common cold symptoms (13%)
• Rise in liver enzymes (up to 13%)
• Bronchitis (12%)
• Weight loss (12%)
• Shortness of breath (11%)
• Headache (11%)
• Cough (10%)
• Stomach pain (10%)
• Tiredness (10%)

SSc-ILD

• Diarrhea (76%)
• Nausea (32%)
• Vomiting (25%)
• Skin ulcer (18%)
• Stomach pain (18%)
• Rise in liver enzymes (11%)

• Liver problems
• Stomach side effects
• Harm to unborn babies
• Blood clots, including heart attacks
• Risk of bleeding
• Tear or hole in the stomach or intestines
• High levels of protein in urine