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Compare Pirfenidone vs. Ofev

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Pirfenidone (Esbriet)
    Ofev (nintedanib)
  • Pirfenidone (Esbriet)
    Ofev (nintedanib)

  • Summary of Pirfenidone vs. Ofev

    Summary for Antifibrotic agent
    Prescription only

    Pirfenidone, also known by its brand name, Esbriet, is an antifibrotic medication used to treat idiopathic pulmonary fibrosis (IPF) in adults, a condition that causes scarring in the lungs. The dose starts low and is slowly raised, and it's taken by mouth three times per day with food. Common side effects include nausea, stomach pain, and skin rash. Because there have been some cases of liver injury from taking this medication, you'll need regular lab work to check your liver health. It's available in both brand-name and generic versions.

    Summary for Tyrosine kinase inhibitor
    Prescription only

    Ofev (nintedanib) is a brand-name medication used to treat adults with certain types of interstitial lung disease (ILD), like idiopathic pulmonary fibrosis. It belongs to a group of medications called tyrosine kinase inhibitors, which work by slowing down the build up of scar tissue in the lungs. You typically take a dose by mouth twice a day with food to lower the chance of side side effects. Some common side effects include diarrhea, nausea, and stomach pain.

  • Indications of Pirfenidone vs. Ofev

    Indications for
    •Idiopathic pulmonary fibrosis (IPF) in adults
    Indications for

    Ofev (nintedanib) treats certain types of interstitial lung disease (ILD):

    •Idiopathic pulmonary fibrosis (IPF)
    •Progressive fibrosing interstitial lung disease (PF-ILD)
    •Systemic sclerosis-associated interstitial lung disease (SSc-ILD)

  • Pros and Cons of Pirfenidone vs. Ofev

    Pros and Const for Antifibrotic agent
    Pros
    •Helps people with idiopathic pulmonary fibrosis (IPF) live longer
    •Can be used with other therapies to treat IPF
    •Capsule or tablet taken by mouth
    Cons
    •Need regular blood tests to check liver health
    •Needs to be taken 3 times a day
    •Stomach-related side effects (e.g., nausea, stomach pain, diarrhea) are common
    Pros and Const for Tyrosine kinase inhibitor
    Pros
    •One of only a few medications approved to treat certain types of ILD
    •Available as capsules taken by mouth
    •Might help you live longer
    Cons
    •Commonly causes stomach side effects like diarrhea, nausea, and vomiting
    •Need regular blood tests to check liver health
    •Raises the risk of bleeding or bruising

  • Common Side Effects of Pirfenidone vs. Ofev

    Common Side Effects for
    •Nausea (36%)
    •Rash (30%)
    •Stomach pain or discomfort (24%)
    •Upper respiratory tract infection (27%)
    •Diarrhea (26%)
    •Tiredness (26%)
    •Headache (22%)
    •Reduced appetite (21%)
    •Indigestion (19%)
    •Dizziness (18%)
    •Vomiting (13%)
    Common Side Effects for

    IPF

    •Diarrhea (62%)
    •Nausea (24%)
    •Stomach pain (15%)
    •Rise in liver enzymes (14%)
    •Vomiting (12%)
    •Reduced appetite (11%)
    •Weight loss (10%)

    PF-ILD

    •Diarrhea (67%)
    •Nausea (29%)
    •Vomiting (18%)
    •Reduced appetite (15%)
    •Common cold symptoms (13%)
    •Rise in liver enzymes (up to 13%)
    •Bronchitis (12%)
    •Weight loss (12%)
    •Shortness of breath (11%)
    •Headache (11%)
    •Cough (10%)
    •Stomach pain (10%)
    •Tiredness (10%)

    SSc-ILD

    •Diarrhea (76%)
    •Nausea (32%)
    •Vomiting (25%)
    •Skin ulcer (18%)
    •Stomach pain (18%)
    •Rise in liver enzymes (11%)

  • Warnings of Pirfenidone vs. Ofev

    Common Side Effects for
    •Liver injury
    •Sunlight sensitivity
    •Severe skin reactions
    •Stomach-related side effects
    Common Side Effects for
    •Liver problems
    •Stomach side effects
    •Harm to unborn babies
    •Blood clots, including heart attacks
    •Risk of bleeding
    •Tear or hole in the stomach or intestines
    •High levels of protein in urine

  • Prices with our coupons for Pirfenidone vs. Ofev

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    Learn more about Ofev

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