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Dayvigo

lemborexant
Used for Insomnia

Dayvigo (lemborexant) CIV is a medication that's used to help adults who have trouble falling or staying asleep (insomnia). This sleep medication belongs to the drug class called orexin receptor antagonists. The typical dosage for the Dayvigo (lemborexant) tablets is 5 mg or 10 mg that's taken by mouth right before bedtime. You should take the medication only if you know you can get at least 7 hours of sleep before you need to wake up the next day. Common side effects include sleepiness and headache. Dayvigo (lemborexant) is a controlled substance because it has a risk for misuse.

Reviewed by:Last reviewed on February 5, 2025
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What is Dayvigo (lemborexant)?

What is Dayvigo (lemborexant) used for?

  • Trouble falling asleep or staying asleep (insomnia)

How Dayvigo (lemborexant) works

Dayvigo (lemborexant) is an orexin receptor antagonist. It works by blocking orexin, a protein in your brain that keeps you awake. By blocking orexin, Dayvigo (lemborexant) can help you fall asleep and stay asleep.

When does Dayvigo (lemborexant) start working?Time passed since treatment started:
MINUTES
Full effect
HOURS
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsDayvigo
Drug ClassOrexin receptor antagonist
Controlled Substance ClassificationSchedule IV
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Risks and warnings for Dayvigo (lemborexant)

Dayvigo (lemborexant) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Daytime sleepiness

  • Risk factors: Taking a higher-than-recommended dose | Taking other medications that cause sleepiness or slow your body down | Age 65 years and older | Drinking alcohol | Having less than 7 hours of sleep

Dayvigo (lemborexant) can make you very sleepy during the daytime. It can also make it harder to focus, think, or react during the day. These side effects are more likely to happen or be more intense if you're 65 years or older. Your risk for these side effects is also higher if you drink alcohol while you're taking Dayvigo (lemborexant) or if you take other medications that cause sleepiness (like benzodiazepines or other sleep medications).

Be sure to take Dayvigo (lemborexant) only if you know you can get at least 7 hours of sleep after you take the medication. If you don't get enough sleep, you're more likely to feel sleepy and have a hard time paying attention the next day.

Don't drive or operate machinery until you know how Dayvigo (lemborexant) affects you. Also don't drive or operate machinery until you're fully alert and you're able to focus. Keep in mind that these side effects can sometimes last for up to several days after the last dose of medication for some people.

Suicidal thoughts and behaviors or worsening depression

  • Risk factors: History of mental health problems, like depression | Insomnia

Some people with depression who take medications like Dayvigo (lemborexant) can have worsening mental health. Their depression could worsen. People who take Dayvigo (lemborexant) might also be at higher risk for having thoughts of suicide, thoughts of harming themselves, or suicidal behavior.

Your prescriber will check for your risk for self-harm and depression before you start Dayvigo (lemborexant). They'll also check in on your mental health at follow-up visits. Let your prescriber know if you have worsening depression (e.g., anxiety, difficulty sleeping, feeling angry or irritated) while you take Dayvigo (lemborexant). Call 911 right away if you or your loved ones notice that you have suicidal thoughts or behaviors.

Sleep paralysis, hallucinations, and cataplexy-like symptoms

Some people who take Dayvigo (lemborexant) might experience sleep paralysis. This happens when you can't move or speak for up to several minutes after you start to wake up. Some people have also had hallucinations (seeing things that aren't real). And others might have cataplexy-like symptoms, like sudden muscle weakness and paralysis that might be set off by sudden, strong emotions like laughter, surprise, or stress. Contact your prescriber if you or your loved ones notice that you have these experiences while you're taking Dayvigo (lemborexant).

Abnormal sleep behaviors

Some people who take sleep medications like Dayvigo (lemborexant) have experienced "complex sleep behaviors." These unusual behaviors can include sleepwalking, sleep-driving, and doing things while they're not completely awake (e.g., cooking and eating food, having a conversation, having sex).

These abnormal sleep behaviors can happen to anyone who takes Dayvigo (lemborexant) and at any time during treatment. And you might not remember doing these things. Stop taking this medication and contact your prescriber right away if your loved ones say that they've noticed these behaviors.

Use with caution in people with breathing problems

  • Risk factors: History of breathing problems (e.g., sleep apnea, chronic obstructive pulmonary disease or COPD)

Let your prescriber know if you have any breathing problems before you start taking Dayvigo (lemborexant). It's not completely clear whether this medication can worsen breathing problems such as sleep apnea or chronic obstructive pulmonary disease (COPD). Talk with your prescriber to see whether Dayvigo (lemborexant) is safe for you to take.

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Side effects of Dayvigo (lemborexant)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Feeling sleepy or tired (up to 10%)
  • Headache (up to 6%)
  • Nightmares or unusual dreams (up to 2%)

Less Common Side Effects

  • Sleep paralysis
  • Hallucinations (seeing or hearing things that aren't real)
  • Weakness in the legs

Dayvigo (lemborexant) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Excessive sleepiness: daytime sleepiness, trouble focusing or staying alert
  • Abnormal sleep behaviors: sleepwalking; sleep-driving; sleeping during activities; sleep paralysis (can't move or talk for several minutes while waking up); eating food, making phone calls, and having sex while asleep
  • Depression: anxiety, trouble sleeping, feeling angry or irritated, restlessness
  • Suicidal thoughts or behaviors
When do Dayvigo (lemborexant) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Risk of daytime sleepiness
Risk of abnormal sleep behaviors (e.g., sleepwalking)
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Dayvigo (lemborexant) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
  • Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
  • Unable to move or speak for several minutes upon waking or going to sleep
  • Unusual sleep behaviors or activities you do not remember such as driving, eating, or sexual activity

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Drowsiness the day after use
  • Fatigue
  • Headache
  • Vivid dreams or nightmares
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Pros and cons of Dayvigo (lemborexant)

Pros

  • Can help you fall asleep faster and stay asleep longer
  • Taken right before you plan to go to sleep
  • Not likely to cause withdrawal if you stop taking the medication suddenly

Cons

  • Can cause daytime sleepiness, especially if you get less than the recommended 7 hours of sleep after you take the medication
  • Not recommended for people with severe liver problems
  • Not known if it's safe or if it works well for children
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Pharmacist tips for Dayvigo (lemborexant)

pharmacist
  • You can take Dayvigo (lemborexant) with or without food. But keep in mind that taking the medication with high-fat and high-calorie foods can make it take a little longer to start working to help you sleep.
  • Take Dayvigo (lemborexant) every night right before you go to bed. Ask your prescriber about your options if you feel like you don't need to take it every night.
  • Only take Dayvigo (lemborexant) if you plan to get at least 7 hours of sleep. If you can't get 7 full hours of sleep after you take the medication, you're more likely to feel sleepier during the daytime the next day.
  • You might feel sleepy the next day after you take Dayvigo (lemborexant). Avoid doing anything that you need to give your full attention to (like driving or operating heavy machinery) until you know how you feel the day after you take the medication. Avoid doing these things until you're fully awake.
  • Avoid drinking alcohol while you're taking Dayvigo (lemborexant). Also, don't take other medications that also make you sleepy while you're taking Dayvigo (lemborexant) unless your prescriber said it's safe for you. It can make side effects like daytime sleepiness worse.
  • Contact your prescriber if Dayvigo (lemborexant) doesn't help with your sleep after you've taken it for up to 10 days. This could mean that your sleep problems are related to a different medical issue.
  • Tell your healthcare team about all of the medications and over-the-counter products that you're taking or planning to take. Your care team can check for interactions that Dayvigo (lemborexant) can have with other medications, like certain antibiotics, seizure medications, and herbal supplements. Your care team can make sure that your medications are safe to take together.
  • Discuss the risks and benefits of breastfeeding while you're taking Dayvigo (lemborexant) with your prescriber or lactating consultant. A low amount of medication can get into breast milk. This might make your breastfed baby sleepy, especially if they're a newborn or if they're premature (born too early).
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Dayvigo (lemborexant) dosage

The average cost for 30 tablets of 10mg of Dayvigo (lemborexant) is $135.00 with a free GoodRx coupon. This is 68.34% off the average retail price of $426.40.
tabletTablet
DosageQuantityPrice as low asPrice per unit
5mg30 tablets$135.00$4.50
10mg30 tablets$135.00$4.50

Typical dosage for Dayvigo (lemborexant)

The typical dose is 5 mg by mouth right before you go to bed. If you're still having trouble sleeping, your prescriber might raise the dose to 10 mg by mouth right before you go to bed.

For most people, the maximum dose for most people is 10 mg per day.

For people with moderate liver problems or for people who are taking certain medications that interact with Dayvigo (lemborexant), the maximum dose is 5 mg per day.

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How much does Dayvigo (lemborexant) cost?

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Dayvigo (lemborexant) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Dayvigo (lemborexant) will not be safe for you to take.

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What are alternatives to Dayvigo (lemborexant)?

There are a number of medications that your doctor can prescribe in place of Dayvigo (lemborexant). Compare a few possible alternatives below.
Dayvigo (lemborexant)
Used for:
  • Trouble falling asleep or staying asleep (insomnia)
$135.00Lowest GoodRx priceView prices
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$7.89Lowest GoodRx priceView prices
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News about Dayvigo (lemborexant)

References

Best studies we found

Drugs and Lactation Database (LactMed®). (2024). Lemborexant. National Institute of Child Health and Human Development.

Eisai Inc. (2025). Dayvigo- lemborexant tablet, film coated [package insert]. DailyMed.

Moline, M., et al. (2023). The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act. Psychopharmacology.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.