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Depression Medications

Find prices and information on Depression medications.

Read our guide toDepression

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Key takeaways

Medications for depression help balance chemicals in the brain to improve your mood. There are several common classes of antidepressants. iSelective serotonin reuptake inhibitors (SSRIs) include fluoxetine (Prozac) and sertraline (Zoloft). Serotonin-norepinephrine reuptake inhibitors (SNRIs) include duloxetine (Cymbalta) and venlafaxine (Effexor XR). Atypical antidepressants include bupropion (Wellbutrin XL) and trazodone. Tricyclic antidepressants (TCAs) include amitriptyline and nortriptyline. And monoamine oxidase inhibitors (MAOIs) include selegiline and phenelzine (Nardil). These medications provide a variety of options for treating depression symptoms.

Prices for popular Depression medications

Viewing 25 of 54 medications

Prozac (fluoxetine)

as low as$5

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Fluoxetine (Prozac) is an inexpensive drug used to treat mood problems such as depression, obsessive compulsive disorder, and panic attacks. It can also treat certain eating disorders. It is available in generic and brand versions. Generic fluoxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Lexapro (escitalopram)

as low as$7

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Escitalopram (Lexapro) is an inexpensive drug used to treat depression and certain types of anxiety. This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Zoloft (sertraline)

as low as$7

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Sertraline (Zoloft) is an inexpensive drug used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD), or social anxiety. It is more popular than comparable drugs. Generic sertraline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Wellbutrin XL (bupropion XL)

as low as$10

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Bupropion XL (Wellbutrin XL) is a moderately priced drug used to treat depression. This drug is slightly more popular than comparable drugs. It is available in brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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trazodone

as low as$7

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Trazodone is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Cymbalta (duloxetine)

as low as$10

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Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. The most common version of Cymbalta is covered by 62% of insurance plans at a co-pay of $60.00-$87.50, however, some pharmacy coupons or cash prices may be lower.

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Celexa (citalopram)

as low as$7

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Citalopram (Celexa) is an inexpensive drug used to treat depression. It is slightly less popular than comparable drugs. This drug is available in generic and brand versions. Generic citalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may lower.

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Abilify (aripiprazole)

as low as$11

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Aripiprazole (Abilify) is an inexpensive drug used to treat schizophrenia and bipolar disorder, also known as manic-depression. It is also used to treat Tourette's disorder and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat major depressive disorder. This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Effexor XR (venlafaxine ER)

as low as$11

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Venlafaxine ER (Effexor XR) is a moderately priced drug used to treat depression. It is also used to treat general anxiety disorder, social anxiety disorder, and panic disorder. This drug is slightly more popular than comparable drugs. It is available in brand and generic form. Generic venlafaxine ER is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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amitriptyline

as low as$4

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Amitriptyline is used to treat depression. It is more popular than comparable drugs. Amitriptyline is only available as a generic drug; all brands have been discontinued. Generic amitriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Paxil (paroxetine)

as low as$12

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Paroxetine (Paxil, Brisdelle) is used to treat depression. It may also be used to treat anxiety disorders, obsessive compulsive disorder, panic attacks, post traumatic stress, and premenstrual dysphoric disorder (PMDD). It is slightly more popular than comparable drugs. It is available in generic and brand versions. Generic paroxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Pristiq (desvenlafaxine succinate ER)

as low as$21

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Desvenlafaxine (Pristiq) is an expensive drug used to treat depression. This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Pamelor (nortriptyline)

as low as$7

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Nortriptyline (Pamelor) is an inexpensive drug used to treat depression. It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic nortriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Remeron (mirtazapine)

as low as$8

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Mirtazapine (Remeron) is an inexpensive drug used to treat depression. It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic mirtazapine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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bupropion

as low as$8

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BUPROPION treats depression. It increases norepinephrine and dopamine in the brain, hormones that help regulate mood. It belongs to a group of medications called NDRIs.

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doxepin

as low as$9

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DOXEPIN reduces itching caused by skin conditions, such as eczema. It works by blocking histamine, a substance released by the body during an allergic reaction.

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Auvelity

as low as$10

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Auvelity (dextromethorphan/bupropion) is used to treat major depressive disorder. It is only available as a brand name drug. It may be covered by your Medicare or insurance plan, but some pharmacy coupons or cash prices could help offset the cost.

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Norpramin (desipramine)

as low as$10

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DESIPRAMINE treats depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called tricyclic antidepressants (TCAs).

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Trintellix

as low as$10

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Trintellix (vortioxetine) is used to treat depression. Trintellix is an atypical antidepressant which works by balancing out cetain chemicals like dopamine and norepinephrine. The most common form of Trintellix is a 10mg tablet. It is also available as a 5mg tablet and a 20mg tablet. There are currently no generic alterantives for Trintellix. It is covered by some Medicare and insurance plans, but some pharmacy coupons, manufacturer programs, or cash prices may be lower.

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Seroquel XR (quetiapine ER)

as low as$12

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QUETIAPINE treats schizophrenia and bipolar disorder. It may also be used with antidepressant medication to treat depression. It works by balancing the levels of dopamine and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It belongs to a group of medications called antipsychotics. Antipsychotic medications can be used to treat several kinds of mental health conditions.

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Wellbutrin SR (bupropion SR)

as low as$12

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Bupropion SR (Wellbutrin SR) is used to treat depression. It is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic bupropion sr is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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amoxapine

as low as$13

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AMOXAPINE treats depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called tricyclic antidepressants (TCAs).

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chlordiazepoxide / amitriptyline

as low as$15

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CHLORDIAZEPOXIDE; AMITRIPTYLINE treats depression and anxiety. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It also works by helping your nervous system calm down. It is a combination of a tricyclic antidepressant (TCA) and a benzodiazepine.

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Tofranil (imipramine hydrochloride)

as low as$16

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IMIPRAMINE treats depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It may also help reduce bedwetting in children. It belongs to a group of medications called tricyclic antidepressants (TCAs).

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venlafaxine

as low as$16

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Venlafaxine is an inexpensive drug used to treat depression. It works by increasing the amount of serotonin and norepinephrine available in the brain. It is slightly less popular than comparable drugs. Venlafaxine is only available as a generic drug; all brands have been discontinued. Generic venlafaxine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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