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Zantac vs. Carafate

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ranitidine (Zantac) and sucralfate (Carafate) are both medications used to treat stomach conditions, but they work in different ways and belong to different medication classes. Ranitidine is a histamine H2 antagonist that was used to treat heartburn, stomach and intestinal ulcers, and gastroesophageal reflux disease (GERD) by reducing stomach acid. However, it has been discontinued in the United States due to concerns about an impurity that could cause cancer. On the other hand, sucralfate is an antiulcer medication that treats duodenal ulcers by forming a protective barrier over the ulcer, allowing it to heal. Sucralfate is available by prescription and comes in both tablet and liquid forms, while ranitidine was available in oral and injectable forms before its recall. Sucralfate must be taken on an empty stomach up to four times a day, and it can interact with other medications, requiring careful timing of doses. Common side effects of sucralfate include constipation. Unlike ranitidine, sucralfate is still available as a generic medication.

Ranitidine

 

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Sucralfate

(Carafate)

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Summary for Zantac

Prescription only

Ranitidine is an H2 blocker that reduces the amount of acid the stomach produces. It's used to treat conditions like gastroesophageal reflux disease (GERD) and ulcers. It was recalled in 2020 due to safety concerns about a chemical impurity, but it has since been reformulated and is now back on the market. Your dose depends on why you’re taking it, but it’s usually taken by mouth one to four times a day. Side effects include headache, dizziness, and feeling tired.

Indications for Zantac

Pros and Cons for Zantac

Pros

  • Reduces stomach acid for ulcers and GERD
  • Can be used in adults and children
  • Works pretty quickly, within hours for GERD

Cons

  • Might need to take multiple times a day
  • Interacts with many medications
  • Not as strong as PPIs for severe symptoms

Common Side Effects for Zantac

  • Headache
  • Tiredness
  • Dizziness
  • Diarrhea
  • Constipation
  • Stomach pain
  • Nausea

Warnings for Zantac

  • Risk of hiding symptoms of a more serious problem
  • Medication interactions
  • Allergic reactions

Summary for Carafate

Prescription only

Sucralfate (Carafate) is a prescription ulcer medication. It treats ulcers in the intestine (duodenal ulcers) in adults. Sucralfate (Carafate) is a protectant; the medication works directly at the site of the ulcer to protect it so it can heal. Although the medication helps ulcers heal, it isn't used to prevent future ulcers. Sucralfate (Carafate) comes in an oral suspension and tablets that are available as brand-name and generic versions. It's taken by mouth up to 4 times per day and it doesn't have many side effects since very little is absorbed from the gut.

Indications for Carafate

  • Short-term treatment (up to 8 weeks) of duodenal ulcer (open sore in the first part of the small intestine) - tablets and oral suspension
  • Maintenance treatment of duodenal ulcer after it's healed - tablets only

Pros and Cons for Carafate

Pros

  • Few side effects since the medication doesn't get absorbed into the body
  • Available as tablets, as well as a liquid for people with trouble swallowing pills
  • Available as a lower-cost generic

Cons

  • Need to take 4 times per day on an empty stomach for the first 1 to 2 months
  • Can affect how other medications are absorbed in the stomach since sucralfate (Carafate) creates a layer that covers the stomach lining
  • Risk of high aluminum levels in the body in people with kidney problems

Common Side Effects for Carafate

  • Constipation (2%)

Warnings for Carafate

  • High aluminum levels

Prices with our coupons for Zantac vs. Carafate

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Ranitidine60 tablets / 150mg
$17.86$458.13
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Sucralfate120 tablets / 1g
$26.78$28.84
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