Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Zaditor (ketotifen) and cromolyn (Crolom) are both eye drops used to treat allergy-related eye symptoms, but they have some key differences. Zaditor is an over-the-counter antihistamine and mast cell stabilizer that works quickly, often within 15 minutes, to relieve itchy eyes. It's suitable for adults and children aged 3 and older and is typically used twice a day. In contrast, cromolyn is a prescription-only mast cell stabilizer that helps with chronic eye allergies, including itching, tearing, and redness. Cromolyn takes longer to start working, often requiring several days to weeks for full effect. It can be used in adults and children as young as 4 years old, and typically used 4 to 6 times a day. While Zaditor shouldn’t be used for more than 3 days in a row, while cromolyn is safe for long-term use. Neither medication should be used with contact lenses due to preservatives that can damage the lenses. Cromolyn is considered a good option for pregnant women, but there isn’t enough information to know whether Zaditor is safe during pregnancy.
Zaditor (ketotifen)
Cromolyn eye drop
Zaditor (ketotifen)
Cromolyn eye drop
Summary of Zaditor vs. Crolom
Summary for Antihistamine
Zaditor (ketotifen) is an antihistamine eye drop that's available over the counter for allergy-related itchy eyes. It works by blocking histamine and stopping your body from releasing chemicals that cause allergy symptoms. Adults and children can use Zaditor (ketotifen). The typical dosage is one drop into the affected eye(s) twice daily. Side effects can include headache, blurry vision, and dry eyes.
Summary for Mast cell stabilizer
Prescription only
Cromolyn eye drop is an ophthalmic drop that helps relieve long-term allergy symptoms related to the eye, such as eye itchiness, watery eyes, and eye redness. It belongs to a drug class called mast cell stabilizers. Cromolyn eye drop is for people over 4 years of age. The usual dosage is 1 or 2 drops in each eye 4 to 6 times a day. It typically takes a few days to a few weeks for symptom relief. The most common side effects are burning or stinging when you apply the eye drops.