Key takeaways
Hydroxyzine (Vistaril) and zolpidem (Ambien) are both prescription medications that can make you sleepy, but they have different FDA-approved uses. Hydroxyzine is an antihistamine that treats allerygy-related symptoms and short-term anxiety. It can make you drowsy as a side effect, but it isn't approved to treat insomnia. Zolpidem, on the other hand, is an FDA-approved insomnia treatment. It can help you fall and stay asleep, although it does carry a risk for behaviors such as sleepwalking or driving while alseep. Zolpidem is also a controlled substance, which means it carries a risk for dependence and misuse.
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