Tyrvaya vs. Xiidra for Dry Eye: Important Differences and Potential Risks.

Tyrvaya

(varenicline)

Xiidra

(lifitegrast)

Summary for Tyrvaya

Prescription only

Tyrvaya (varenicline) is a cholinergic agonist. It's a nasal spray used to treat dry eye in adults. This medication is sprayed into each nostril, typically twice a day. Some side effects of Tyrvaya (varenicline) include sneezing, cough, and throat irritation.

Indications for Tyrvaya

Dry eye

Pros and Cons for Tyrvaya

Pros

Can relieve dry eyes in as quickly as 5 minutes
Can cause eyes to make 50% more tears after a month of treatment
Can be stored at room temperature

Cons

Must be used twice a day and in each nostril
Brand name only
Commonly causes sneezing as a side effect

Common Side Effects for Tyrvaya

Sneezing (82%)
Cough (16%)
Throat irritation (13%)
Nose irritation (8%)

Summary for Xiidra

Prescription only

Xiidra (lifitegrast) is an eye drop medication that treats dry eye in adults. It belongs to a drug class called LFA-1 antagonists. It's thought to help lower inflammation and other symptoms of dry eye. Usually, you need to use Xiidra (lifitegrast) every day. You put 1 drop into each eye twice a day. Side effects include temporary eye irritation and unclear vision. At this time, Xiidra (lifitegrast) is available only as a brand medication. There's no generic version yet.