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Compare Trulicity vs. Mounjaro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Trulicity (dulaglutide) and Mounjaro (tirzepatide) are both once-weekly injectable medications used to manage Type 2 diabetes. However there are some important differences. Trulicity is a GLP-1 receptor agonist, while Mounjaro is both a GLP-1 and GIP receptor agonist. Trulicity is approved for people 10 years and older, while Mounjaro is only approved for adults. Trulicity also has an additional FDA-approved indication to lower the risk of heart problems in adults with Type 2 diabetes who have heart disease or risk factors. The starting dose for Trulicity is 0.75 mg, with a maximum of 4.5 mg weekly for adults, whereas Mounjaro starts at 2.5 mg and can go up to 15 mg weekly. Both are only available as branded medications. Common side effects for both include nausea, vomiting, and diarrhea and an increased risk of thyroid cancer and pancreatitis. They should not be used by people with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2.

  • Trulicity (dulaglutide)
    Mounjaro (tirzepatide)
  • Trulicity (dulaglutide)
    Mounjaro (tirzepatide)

  • Summary of Trulicity vs. Mounjaro

    Summary for GLP-1 agonist
    Prescription only

    Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

    Summary for GIP and GLP-1 agonist
    Prescription only

    Mounjaro (tirzepatide) is a prescription injection used to improve blood sugar control in adults with Type 2 diabetes. It works best when you also follow a nutritious diet and exercise regularly. Mounjaro (tirzepatide) belongs to the drug class called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea and diarrhea. It can also lower your appetite, which might lead to some weight loss.

  • Indications of Trulicity vs. Mounjaro

    Indications for
    •Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
    •Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors
    Indications for
    •Type 2 diabetes, in addition to a balanced diet and routine exercise

  • Pros and Cons of Trulicity vs. Mounjaro

    Pros and Const for GLP-1 agonist
    Pros
    •Works well at lowering A1C
    •Comes as a ready-to-use injectable pen
    •Only used once a week
    •Helps with weight loss
    Cons
    •Commonly causes nausea, vomiting, diarrhea, and stomach pain
    •Potential risk for thyroid tumors
    •Can cause problems in the pancreas, kidney, and gallbladder
    •Not recommended for people with stomach problems
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Given once weekly
    •Can lower A1C by an average of up to 2.3% in about 9 months
    •Injections can be given with or without food
    •Comes in vials and ready-to-use injectable pens
    •Can use if you have liver or kidney problems
    Cons
    •Only available as an injection given under the skin
    •Can cause unpleasant side effects like nausea, vomiting, and diarrhea
    •Takes time to reach a dose that works well
    •Not approved for children
    •Might not be safe during pregnancy

  • Common Side Effects of Trulicity vs. Mounjaro

    Common Side Effects for
    •Nausea (12-21%)
    •Diarrhea (7-13%)
    •Vomiting (6-13%)
    •Stomach pain (7-9%)
    •Low appetite (5-9%)
    •Fatigue (4-6%)
    •Indigestion (3-6%)
    Common Side Effects for
    •Nausea (12-18%)
    •Diarrhea (12-17%)
    •Low appetite (5-11%)
    •Vomiting (5-9%)
    •Indigestion (5-8%)
    •Constipation (6-7%)
    •Stomach pain (5-6%)

  • Warnings of Trulicity vs. Mounjaro

    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar when used with certain diabetes medications
    •Severe allergic reactions
    •Kidney damage
    •Severe stomach-related side effects
    •Worsening eye problems in people with diabetic retinopathy
    •Gallbladder problems
    •Breathing fluid into your lungs during anesthesia or deep sedation
    Common Side Effects for
    •Risk of thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar (hypoglycemia) when used with other diabetes medications
    •Allergic reactions
    •Stomach side effects
    •Kidney damage due to dehydration
    •Eye problems in people with diabetic retinopathy
    •Gallbladder problems
    •Lung problems during general anesthesia or deep sedation

  • Prices with our coupons for Trulicity vs. Mounjaro

    Learn more about Trulicity
    Learn more about Mounjaro

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