Key takeaways
Trazodone (Desyrel) and bupropion (Wellbutrin) are both atypical antidepressants used to treat depression. Trazodone is sometimes used off-label for insomnia, while bupropion is also approved for seasonal affective disorder (SAD). Trazodone is a serotonin antagonist and reuptake inhibitor (SARI), while bupropion works by boosting norepinephrine and dopamine levels. Trazodone is typically taken in divided doses throughout the day, whereas bupropion is available in immediate-release, sustained-release, and extended-release forms, and is usually taken 1 to 3 times daily, depending on the dosage form. Both medications are available as generics, but trazodone is not a first-choice option for depression. Common side effects of trazodone include sleepiness and dizziness, while bupropion may cause headache, dry mouth, or nausea. Trazodone can interact with other medications affecting serotonin levels, increasing the risk of serotonin syndrome, while bupropion can increase the risk of seizures, especially in those with a history of seizures or eating disorders.
