Key takeaways
Tizanidine (Zanaflex) and meloxicam (Mobic) are both prescription medications, but they belong to different classes and treat different conditions. Tizanidine is an alpha-2 adrenergic receptor agonist used as a muscle relaxer to treat muscle stiffness and rigidity, while meloxicam is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain from arthritis. Tizanidine is taken orally, typically three times a day, and is available in both tablet and capsule forms, with a lower-cost generic option. Meloxicam can be taken as a capsule, tablet, liquid, or injection, is usually taken once daily, and also comes as a lower-cost generic. Some medications, like ciprofloxacin, can worsen low blood pressure and dizziness when taken with tizanidine. Meloxicam, on the other hand, can cause stomach upset, diarrhea, and joint pain, and should not be taken with other NSAIDs. While tizanidine is not known to cause addiction, it can lead to withdrawal symptoms if stopped suddenly. Meloxicam is not safe during pregnancy and can increase the risk of heart attack or stroke, especially if taken for a long time.
