Key takeaways
Metaxalone (Skelaxin) and orphenadrine ER (Norflex) are both muscle relaxants used to relieve muscle pain and discomfort. Metaxalone is typically taken three to four times a day, while orphenadrine ER is taken twice a day. Metaxalone is less likely to cause drowsiness compared to other muscle relaxants, but it can still make you sleepy and dizzy. Orphenadrine ER can also cause drowsiness, along with dry mouth and headache. Metaxalone is not a controlled substance and has a lower risk of addiction, whereas orphenadrine ER has some potential for misuse and addiction. Orphenadrine ER is available in both tablet and injectable forms, while metaxalone is only available as a tablet. Additionally, orphenadrine ER is not recommended for older adults and people with certain conditions like glaucoma or heart problems, whereas metaxalone should be used cautiously in people with severe kidney or liver issues. Both medications are available as lower-cost generics.
