Key takeaways
Quetiapine (Seroquel) and brexpiprazole (Rexulti) are both atypical antipsychotics used to treat schizophrenia and depression, but they have some key differences. Quetiapine is available in both immediate-release and extended-release forms and is also used to treat bipolar disorder. In contrast, brexpiprazole can also be used for dementia-related agitation from Alzheimer's disease. Quetiapine often needs to be taken multiple times a day, whereas brexpiprazole is typically taken once daily. Both medications can cause weight gain and high blood sugar, but this is more commonly observed with quetiapine. Additionally, both can cause serious side effects like suicidal thoughts and neuroleptic malignant syndrome and are available as low-cost generics.
