Key takeaways
Quetiapine (Seroquel) and lithium (Lithobid) are both used to treat bipolar disorder, but they have some key differences. Quetiapine is an atypical antipsychotic that can also treat schizophrenia and be used as an add-on for depression. It works by balancing dopamine and serotonin levels in the brain. Lithium, on the other hand, is a mood stabilizer specifically for bipolar disorder and manic episodes. Quetiapine is available in both immediate-release and extended-release forms, while lithium comes in instant-release pills, oral liquid, and extended-release tablets. Quetiapine can cause side effects like weight gain, high blood sugar, and high cholesterol levels, whereas lithium can lead to side effects such as shakiness, thirst, and excessive urination. Both medications require careful monitoring, but lithium needs regular blood tests to check its levels in your body to avoid toxicity. Quetiapine is generally not recommended for older adults with dementia-related psychosis, while lithium is not recommended for those with kidney problems.
