Key takeaways
Temazepam (Restoril) and hydroxyzine pamoate (Vistaril) are both used to help with sleep, but they belong to different medication classes. Temazepam is a benzodiazepine, while hydroxyzine pamoate is an antihistamine. Temazepam is specifically FDA-approved for short-term treatment of insomnia, whereas hydroxyzine pamoate can be used off-label as a sleep aid. Temazepam is a controlled substance due to its potential for misuse and addiction, while hydroxyzine pamoate is not. Temazepam is typically taken once daily at bedtime as needed, whereas hydroxyzine pamoate can be taken up to four times a day. Common side effects of temazepam include drowsiness and headache, while hydroxyzine pamoate often causes sleepiness and dry mouth. Temazepam can interact dangerously with opioids and alcohol. Hydroxyzine pamoate can cause an abnormal heart rhythm, especially if taken with other medications that affect the heart. Both medications are available as a lower-cost generic.
