Key takeaways
Relenza (zanamivir) and Xofluza (baloxavir marboxil) are both antiviral medications used to treat and prevent the flu, but they have some key differences. Relenza is inhaled through a Diskhaler, while Xofluza is taken orally as a tablet or liquid. Relenza must be taken twice a day for 5 days to treat the flu, whereas Xofluza requires only a single dose. Relenza is not suitable for people with asthma or COPD due to the risk of bronchospasm, but Xofluza can be used by a wider range of people, including those with lung conditions. Xofluza is generally well-tolerated and can be taken with or without food, but you should avoid taking it with dairy products or supplements containing calcium, iron, magnesium, selenium, or zinc. Both medications are brand-only and might be more expensive. Both medications need to be started within 48 hours of flu symptoms to be effective, but Relenza has a more complex administration process compared to the single-dose convenience of Xofluza.
