Key takeaways
Prozac (fluoxetine) and Celexa (citalopram) are both selective serotonin reuptake inhibitors (SSRIs) used to treat depression, but they have some differences. Prozac is also approved for treating obsessive-compulsive disorder (OCD), bulimia, panic disorder, and to help treat depression from bipolar 1 disorder, while Celexa is only approved for depression. Prozac can be taken as an immediate-release pill or liquid daily, or as a delayed-release capsule weekly, whereas Celexa is typically taken once daily. Common side effects of Prozac include headaches, difficulty sleeping, and tiredness, while Celexa commonly causes nausea and dry mouth. Both medications can cause withdrawal symptoms if stopped suddenly and have a risk of worsening depression and suicidal thoughts, especially in those 24 and under. Additionally, both can lead to a rare but serious condition called serotonin syndrome if taken with other medications that raise serotonin levels.
