Key takeaways
Pravastatin (Pravachol) and atorvastatin (Lipitor) are both statins used to lower cholesterol and reduce the risk of heart problems. While both medications work by blocking a protein in your liver that makes cholesterol, there are some differences between them. Pravastatin is considered a low-to-moderate intensity statin, whereas atorvastatin is a moderate-to-high intensity statin, meaning atorvastatin can lower cholesterol more effectively at higher doses. Pravastatin is typically taken at night, while atorvastatin can be taken at any time of the day. Atorvastatin is available in both tablet and liquid forms, making it easier for those who have trouble swallowing pills. Both medications can cause serious side effects like muscle damage and liver problems, but atorvastatin has a higher risk of interactions with other medications. Neither medication is safe to use during pregnancy or breastfeeding.
