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Procardia XL vs. Coreg

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Nifedipine ER (Procardia XL) and carvedilol (Coreg) are both used to treat high blood pressure, but they belong to different medication classes and have different uses and side effects. Nifedipine ER is a calcium channel blocker that relaxes blood vessels to lower blood pressure and treat chest pain (angina). It is taken once daily in its extended release form and is available in a generic form. Common side effects include swelling in the legs, dizziness, and headaches. Carvedilol, on the other hand, is a beta blocker that not only lowers blood pressure by relaxing blood vessels but also slows down the heart rate. It is used to manage heart failure and reduce the risk of death after a heart attack. Carvedilol is taken twice daily in its immediate-release form or once daily in its extended-release form, and it is also available as a generic. Common side effects include dizziness, tiredness, and diarrhea. Unlike nifedipine, carvedilol should be taken with food to reduce the risk of a sudden drop in blood pressure. Additionally, carvedilol can hide symptoms of low blood sugar and should be used cautiously in people with asthma or other breathing problems.

Nifedipine ER

(Procardia XL)

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Carvedilol

(Coreg)

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Summary for Procardia XL

Prescription only

Nifedipine (Procardia, Procardia XL) is a calcium channel blocker (CCB). It's used to treat certain heart conditions, such as chest pain (angina) and high blood pressure in adults. It mainly works by relaxing your blood vessels, making it easier for blood to flow. Nifedipine is available as an extended-release pill (ER) that's taken by mouth once daily, and a immediate-release pill (IR) that's taken three times a day. Keep in mind the nifedipine IR is rarely prescribed. Some side effects of nifedipine include swelling in the legs, dizziness, tiredness, and headache.

Indications for Procardia XL

  • Chest pain (angina)
  • High blood pressure (hypertension) - extended-release tablets only

Pros and Cons for Procardia XL

Pros

  • Lowers risk of heart attack and stroke in people with high blood pressure
  • Can take it alone or with other medications to help with blood pressure or chest pain
  • Calcium channel blockers, such as nifedipine ER (Procardia XL), work especially well for Black people to lower blood pressure
  • The extended-release tablets are taken once daily
  • Available as a lower-cost, generic form

Cons

  • Often causes swelling in the legs and feet
  • Not a good choice if you have heart failure because of risk for swelling
  • If you have severe heart disease, it can raise your risk of having a heart attack or worsening chest pain
  • The immediate-release capsule needs to be taken 3 to 4 times a day

Common Side Effects for Procardia XL

Extended-release tablets:

  • Swelling (edema) in the legs, feet, or hands (10-30%)
  • Headache (16%)
  • Fatigue (6%)
  • Dizziness (4%)

Immediate-release capsules:

  • Dizziness or lightheadedness (27%)
  • Flushing (25%)
  • Headache (23%)
  • Weakness (12%)
  • Nausea (11%)
  • Swelling (10%)

Warnings for Procardia XL

  • Low blood pressure
  • Risk of worsening chest pain or heart attack
  • Risk of heart failure
  • Swelling in legs and feet
  • Stomach or intestinal injury (extended-release form only)

Summary for Coreg

Prescription only

Carvedilol (Coreg) is used to treat high blood pressure, manage heart failure, and help with heart problems after a heart attack. It belongs to the beta blocker drug class. This medication comes as a tablet that's taken by mouth twice daily, and as an oral extended-release (ER) capsule (brand name Coreg CR) that's taken once daily. Common side effects include dizziness, feeling tired, and diarrhea.

Indications for Coreg

  • High blood pressure
  • Heart failure
  • Lower the risk of death from heart-related problems after a heart attack

Pros and Cons for Coreg

Pros

  • Taken by mouth
  • Comes as a once-daily extended-release formulation
  • Dose can be adjusted based on your response
  • Available as a lower-cost generic

Cons

  • Need to take with food
  • Can cause you to feel more tired
  • Can cause dry eyes if you wear contact lenses
  • Shouldn't be taken if you have asthma or an asthma-related condition

Common Side Effects for Coreg

  • Dizziness (6%)

Please note: These side effects were reported by people who took carvedilol (Coreg) in clinical studies for high blood pressure.

Warnings for Coreg

  • Worsening chest pain and heart attacks
  • Slow heart rate and low blood pressure
  • Heart failure
  • Hiding symptoms of low blood sugar
  • Risk of difficulty breathing
  • Hiding symptoms of high thyroid hormone
  • Risk of kidney problems
  • Severe allergic reactions
  • Greater risk during surgery
  • Risk of eye problems during surgery

Prices with our coupons for Procardia XL vs. Coreg

Price Card Drug Icon
Nifedipine ER (Procardia XL)30 tablets / 30mg
$17.87$19.65
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Carvedilol180 tablets / 25mg
$22.74$115.48
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