Key takeaways
Polyethylene glycol 3350 (Miralax) and docusate/senna (Senna-S) are both over-the-counter options for treating occasional constipation, but they work differently. Miralax is an osmotic laxative that draws water into your colon to soften stool, typically resulting in a bowel movement within 1 to 3 days. In contrast, Senna-S combines a stool softener (docusate) and a stimulant laxative (senna), which helps to both soften the stool and stimulate bowel movements, usually within 6 to 12 hours. Miralax is taken once a day, while Senna-S is often taken at bedtime to produce a morning bowel movement. Miralax is tasteless and mixed with a beverage, whereas Senna-S is taken in pill form. Both medications should only be used short-term and can cause side effects like bloating and stomach cramps. If you need to use either medication for more than a week, you should consult your healthcare provider.
