Key takeaways
Docusate (Colace) and Symproic (naldemedine) are both used to treat constipation, but they work in different ways and are used for different types of constipation. Docusate is an over-the-counter stool softener that helps with occasional constipation by drawing water and fat into your stool, making it easier to pass. It comes in various forms, including capsules and liquid, and can be used by both adults and children. On the other hand, Symproic is a prescription-only medication specifically for constipation caused by opioid pain medications. It works as an opioid antagonist, blocking the constipating effects of opioids in the gut. Symproic is taken once daily and is not a laxative. Symproic can be expensive and is not suitable for people taking opioids for cancer pain or those who have been on opioids for less than a month. While docusate is generally safe for short-term use, Symproic carries risks like gastrointestinal tears and opioid withdrawal symptoms.
