Key takeaways
Relistor (methylnaltrexone) and Symproic (naldemedine) are both opioid antagonists used to treat constipation caused by opioid pain medications. Relistor is available in both oral and injectable forms, while Symproic is only available as an oral tablet. You need to take Relistor on an empty stomach, but you can take Symproic with or without food. Relistor can work quickly, especially in its injectable form, often within 4 hours, whereas Symproic's timing isn't specified. Relistor is also used for people with advanced illnesses, but Symproic can't be used for those taking opioids for cancer pain. Both medications can be expensive since they are brand-name only. Common side effects for both include abdominal pain, diarrhea, and nausea.
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