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Symproic Coupon - Symproic 0.2mg tablet

Symproic

naldemedine
Used for Constipation
Used for Constipation

Symproic (naldemedine) is a prescription opioid antagonist. More specifically, it's a peripherally acting mu-opioid receptor antagonist (PAMORA) that targets opioid receptors in the gut. It's a first-choice treatment option for opioid-induced constipation in adults. It comes as a tablet that's taken by mouth once per day with or without food. Side effects include stomach pain, diarrhea, and nausea. Symproic (naldemedine) is brand name only and not available as a generic.

Last reviewed on December 11, 2024
basics-icon

What is Symproic (naldemedine)?

What is Symproic (naldemedine) used for?

How Symproic (naldemedine) works

People who take opioid medications for pain commonly experience constipation as a side effect. This is because opioid receptors are found in the brain and the gut. Opioid medications ease pain by affecting the receptors in the brain, but they cause constipation when they affect the receptors in the gut.

Symproic (naldemedine) is a peripherally acting mu-opioid receptor antagonist (PAMORA). This means that it blocks opioid receptors in the gut only, but not in the brain. As a result, Symproic (naldemedine) relieves constipation from opioid medications, without affecting their pain-relieving actions.

Drug Facts

Common BrandsSymproic
Drug ClassOpioid antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$552.07(save 14.47%)
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$472.20
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What are the side effects of Symproic (naldemedine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (11%)
  • Diarrhea (7%)
  • Nausea (6%)

Other Side Effects

  • Vomiting
  • Gut inflammation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Stomach tear: severe, persistent, or worsening stomach pain
  • Opioid withdrawal: mood changes, anxiety, irritability, restlessness, stomach cramps, sweating, chills
  • Serious allergic reaction: rash, swelling in the face or throat, trouble breathing

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Symproic (naldemedine)

thumbs-up

Pros

Good option if over-the-counter stool softeners or laxatives don't work well

Taken by mouth once a day

Most people have bowel movement within 24 hours

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Cons

Tablet only; might be hard to take for people who have trouble swallowing

Only for adults

Raises your risk for opioid withdrawal

pharmacist-tips

Pharmacist tips for Symproic (naldemedine)

pharmacist
  • You can take Symproic (naldemedine) with or without food. If it's hurting your stomach, try taking it with food to help.

    • Your healthcare will ask you to stop taking Symproic (naldemedine) once you no longer need to take opioid pain medications. Opioid-related constipation will go away on its own when you stop taking opioids.

      • Your prescriber might recommend taking Symproic (naldemedine) alone for a few days to see how you respond to the medication. If you're still constipated, ask your prescriber if you should use other laxatives with Symproic (naldemedine).

        • Seek medical help if you experience severe, continuous stomach pain. This can be a sign of a serious stomach tear that Symproic (naldemedine) can rarely cause. You'll need to be seen and treated urgently.

          • Symproic (naldemedine) can sometimes cause diarrhea. Make sure to stay hydrated if you have diarrhea while you're taking this medication. Seek medical help if you feel dizzy, lightheaded, or if your symptoms don't get better after a few days.

            • Make sure to tell your care team about all of the prescription and over-the-counter medication you take. Symproic (naldemedine) interacts with many medications, and these interactions can be harmful.

              faqs

              Frequently asked questions about Symproic (naldemedine)

              Does Symproic (naldemedine) cause weight gain?
              No, weight gain isn't a typical side effect of Symproic (naldemedine). Let your healthcare team know if you experience unexpected weight gain after you start Symproic (naldemedine). They can help figure out the cause and recommend tips to help you maintain a healthy body weight.
              How long does it take for Symproic (naldemedine) to start working?
              Studies show most people had a bowel movement within 24 hours of starting Symproic (naldemedine). It can take about a week to get the maximum benefit from the medication. Keep taking Symproic (naldemedine) every day and follow up with your prescriber if you're concerned with how well the medication is working for you.
              Is Symproic (naldemedine) a controlled substance?
              No. When Symproic (naldemedine) was first FDA-approved, it was classified as a schedule II controlled substance because it can be derived from opium alkaloids. But after further review, the Drug Enforcement Administration (DEA) removed this classification because this medication is not an opioid pain medication. Instead, Symproic (naldemedine) is an opioid antagonist that helps treat constipation from opioid medications, which are controlled substances.
              Is Symproic (naldemedine) the same as Relistor (methylnaltrexone)?
              No, Symproic (naldemedine) and Relistor (methylnaltrexone) aren't the same, but they're similar. Both are peripherally acting mu-opioid receptor antagonist (PAMORA) used to treat constipation from opioids. They're taken by mouth once per day and have similar side effects (e.g., stomach pain, diarrhea, nausea). One difference is that Relistor (methylnaltrexone) is also available as an injection under the skin, while Symproic (naldemedine) isn't. Treatment guidelines recommend both medications for the treatment of constipation due to opioids. Talk to your healthcare professional if you have more questions about the differences between both medications.
              Does Symproic (naldemedine) cause withdrawal?
              Though not common, it's possible for Symproic (naldemedine) to cause opioid withdrawal symptoms, like sweating, chills, fever, and stomach pain. People who have medical conditions that affects the blood–brain barrier (BBB), such as stroke or brain injury, are at higher risk for this side effect. Contact your prescriber right away if you notice any withdrawal symptoms.
              When is the best time to take Symproic (naldemedine)?
              Symproic (naldemedine) can technically be taken at any time of day. But you might consider taking it in the morning since it can make you go to the bathroom. Let your prescriber know if taking Symproic (naldemedine) in the morning isn't possible for you to discuss the best time of day to take the medication.
              Is there a generic for Symproic (naldemedine)?
              No, there isn't a generic version of Symproic (naldemedine) available yet.
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              What are the risks and warnings for Symproic (naldemedine)?

              Symproic (naldemedine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Gastrointestinal (stomach or intestinal) injury

              • Risk factors: Gastrointestinal cancer | Recent gastrointestinal surgery | Gastrointestinal inflammation such as Crohn's disease, diverticulitis, or colitis

                In some rare cases, people who've taken Symproic (naldemedine) reported having stomach or gut problems, including inflammation or a tear in the wall of the gut. This can be dangerous and require hospitalization. Before you start Symproic (naldemedine), let your prescriber know if you have a history of bowel or gut-related problems. Notify your healthcare team right away if you have severe stomach pain, stomach pain that doesn't go away, worsening stomach pain, chills, or fever.

                risk-warning

                Opioid withdrawal

                • Risk factors: Brain injury | Stroke

                  Although rare, some people who took Symproic (naldemedine) experienced withdrawal symptoms, such as sweating, chills, diarrhea, stomach pain, anxiety, and irritability. In some rare cases, you might also get less pain relief from your opioid medication. People who have medical conditions that affects the blood–brain barrier (BBB), such as stroke or brain injury, are at higher risk for these side effects. Talk to your prescriber if you experience any withdrawal symptoms or if your pain medication isn't working as well anymore.

                  dosage

                  Symproic (naldemedine) dosage forms

                  The average cost for 30 tablets of 0.2mg of Symproic (naldemedine) is $472.20 with a free GoodRx coupon. This is 14.47% off the average retail price of $552.07.
                  tablet
                  Tablet
                  DosageQuantityPrice as low asPrice per unit
                  0.2mg30 tablets$472.20$15.74

                  Typical dosing for Symproic (naldemedine)

                  Adults: The typical dose is 0.2 mg by mouth once a day.

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                  How much does Symproic (naldemedine) cost?

                  To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                  contraindications-icon

                  Symproic (naldemedine) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Symproic (naldemedine) will not be safe for you to take.
                  • Known or suspected blockage in the gut

                  alternatives

                  What are alternatives to Symproic (naldemedine)?

                  There are a number of medications that your doctor can prescribe in place of Symproic (naldemedine). Compare a few possible alternatives below.
                  Symproic (naldemedine)
                  Used for:
                  $472.20 Lowest GoodRx priceView Prices
                  Used for:
                  • Constipation due to opioid pain medications

                  $2437.96 Lowest GoodRx priceView Prices
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                  Symproic (naldemedine) images

                  Yellow Round 0.2 And Logo 222 - Symproic 0.2mg Tablet
                  This medicine is Yellow, Round Tablet Imprinted With "Logo 222" And "0.2".Yellow Round 0.2 And Logo 222 - Symproic 0.2mg Tablet

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                  References

                  Best studies we found

                  BioDelivery Sciences International Inc. (2022). Symproic- naldemedine tablet [package insert]. DailyMed.

                  Carlin, M. G., et al. (2020). Opium alkaloids in harvested and thermally processed poppy seeds. Frontiers in Chemistry.

                  Crockett, S. D., et al. (2019). American Gastroenterological Association Institute Guideline on the medical management of opioid-induced constipation. Gastroenterology.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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