Miralax vs. Colace for Constipation: Important Differences and Potential Risks.

Key takeaways

Polyethylene glycol 3350 (Miralax) and docusate sodium (Colace) are both over-the-counter medications used to treat constipation, but they work differently. Miralax is an osmotic laxative that draws water into your colon to soften your stool, making it easier to pass. It usually takes 1 to 3 days to work and is taken once a day. On the other hand, Colace is a stool softener that draws water and fat into your stool to make it softer, which helps it move through your gut more easily. Colace typically works within 12 to 72 hours and can be taken in multiple doses throughout the day. Miralax is available as a powder that you mix with a beverage, while Colace comes in capsules and liquid forms. Both medications should only be used for short-term relief of constipation, and you should consult your healthcare provider if you need to use them for more than a week. Common side effects of Miralax include nausea, bloating, and gas, whereas Colace can cause stomach cramping and, less commonly, throat irritation if taken in liquid form.

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Miralax Vs. Colace For Constipation: 5 Key Differences To Consider

Polyethylene glycol

(Miralax)

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Docusate

(Colace)

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Summary for Miralax

Over-the-counter

Polyethylene glycol (Miralax) is an over-the-counter (OTC) medication used for occasional constipation. It comes as a powder that you need to mix with a beverage and then drink. Typically, you take a dose of polyethylene glycol (Miralax) once a day, for up to a week. Most people will experience a bowl movement in 1 to 3 days. Some side effects that polyethylene glycol (Miralax) can cause include nausea, bloating, and passing gas.

Indications for Miralax

Occasional constipation and irregular bowel movements

Pros and Cons for Miralax

Pros

Available OTC, so you don't need a prescription from your provider
Causes less cramping, bloating, gas, or feelings of "having to go right now" compared to other laxatives
A possible option during pregnancy, if provider says it's safe for you to take

Cons

Can take a few days before you have a bowel movement
Only for short-term relief of constipation
Might cause loose, watery stools

Common Side Effects for Miralax

Nausea
Passing gas
Bloating

Warnings for Miralax

Complete or partial blockage of intestines

Summary for Colace

Over-the-counter

Docusate, often known by the brand name Colace, is a stool softener that you can find over the counter (OTC). It helps relieve constipation in adults and children. You take this medication by mouth, and it comes as capsules, tablets, and a liquid. The dosage depends on the formulation you have and your age. Side effects aren't common, but some people might have stomach cramps. Even though Colace is a popular brand name, docusate is also sold under many other brand names and as a generic.