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Miebo vs. Xiidra

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Miebo

(perfluorohexyloctane)

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Xiidra

(lifitegrast)

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Summary for Miebo

Prescription only

Miebo (perfluorohexyloctane) is a prescription eye drop that's used to treat dry eyes in adults. It's a semifluorinated alkane eye drop that forms a layer on the eye(s) to prevent tears from drying out. The most common side effects of Miebo (perfluorohexyloctane) are blurry vision and eye redness. Currently, it's only available under the brand name Miebo.

Indications for Miebo

Pros and Cons for Miebo

Pros

  • Preservative-free
  • Not many side effects
  • Stored at room temperature, which is convenient for traveling

Cons

  • Needs to be applied 4 times a day
  • Not known if safe for use in children
  • Can cause blurred vision and eye redness

Common Side Effects for Miebo

  • Blurred vision (1-3%)
  • Eye redness (1-3%)

Warnings for Miebo

  • Use with contact lenses

Summary for Xiidra

Prescription only

Xiidra (lifitegrast) is an eye drop medication that treats dry eye in adults. It belongs to a drug class called LFA-1 antagonists. It's thought to help lower inflammation and other symptoms of dry eye. Usually, you need to use Xiidra (lifitegrast) every day. You put 1 drop into each eye twice a day. Side effects include temporary eye irritation and unclear vision. At this time, Xiidra (lifitegrast) is available only as a brand medication. There's no generic version yet.

Indications for Xiidra

Pros and Cons for Xiidra

Pros

  • Works to help treat dry eye in the long run
  • Might be less likely to cause burning in the eyes than Restasis (cyclosporine)

Cons

  • Won't give you instant relief and have to take for a couple weeks before it starts working
  • Not approved for people younger than 17 years old

Common Side Effects for Xiidra

  • Eye irritation (5-25%)
  • Strange taste in the mouth (5-25%)
  • Unclear vision (5-25%)

Warnings for Xiidra

  • Risk of contamination

Prices with our coupons for Miebo vs. Xiidra

Price Card Drug Icon
Miebo1 dropper / 3ml of 1.338g/ml
$798.97$1,022.80
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Price Card Drug Icon
Xiidra1 carton / 60 ampules of 5%
$717.29$917.45
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