Key takeaways
Malarone (atovaquone/proguanil) and Plaquenil (hydroxychloroquine) are both used to prevent and treat malaria, but they have some key differences. Malarone is a combination of two medications, atovaquone and proguanil, and is taken once per day. It is also used specifically for malaria caused by *Plasmodium falciparum*. Plaquenil, on the other hand, is a single medication that can be taken once or twice per day and is also used to treat rheumatoid arthritis and lupus in adults. Malarone is not recommended for people with severe kidney or liver problems, while Plaquenil can cause serious side effects like heart rhythm problems and eye damage. Additionally, Malarone is not recommended for pregnant or breastfeeding women, whereas Plaquenil may be considered during pregnancy if the benefits outweigh the risks. Both medications are available as lower-cost generics.
