Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Betamethasone (Diprolene) and fluocinonide (Vanos) are both strong topical corticosteroids used to treat skin inflammation and itching. Betamethasone comes in various forms, including creams, ointments, gels, lotions, sprays, and foams, while fluocinonide is available as a cream, ointment, gel, and topical solution. Betamethasone can be used for up to 2 weeks for most formulations, but the Sernivo spray can be used for up to 4 weeks. Fluocinonide's higher strength (0.1%) should only be used for 2 weeks, while the lower strength (0.05%) can be used for longer but not chronically. Betamethasone is generally stronger than fluocinonide, and its augmented formulations absorb faster and are more potent. Both medications should not be used on sensitive areas like the face, groin, or armpits, but fluocinonide's lower strength might be used on the face for short periods under a doctor's guidance. Both medications can cause hormone changes and skin reactions if used improperly or for too long.
Betamethasone
Fluocinonide
Betamethasone
Fluocinonide
Summary of Diprolene vs. Vanos
Summary for Corticosteroid
Prescription only
Betamethasone is a potent (strong) medication used to relieve the inflammation (redness, swelling, warmth, pain) and itching from different skin conditions. This medication is available as many different formulations, but most can only be used for up to 2 weeks at a time.
Summary for Corticosteroid
Prescription only
Fluocinonide is a strong topical steroid that's applied on the skin. It treats rashes and skin irritation in adults and children. The medication comes as a cream, ointment, gel, and topical solution. All topical forms come as generics, but the cream is also available under the brand name Vanos. You apply fluocinonide to the affected skin one to four times a day, depending on the formulation. This medication isn't meant for long-term use because of potential side effects like skin thinning and changes in skin color.
Indications of Diprolene vs. Vanos
Indications for
•Inflammation and itchy skin conditions
•Mild-to-moderate plaque psoriasis in people 18 years or older - Sernivo brand only