Skip to main content

Compare
Ibuprofen vs. Percocet

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ibuprofen (Advil, Motrin) and oxycodone / acetaminophen (Percocet) are pain medications. Most forms of ibuprofen are available over-the-counter (OTC) and it’s often considered a first-choice medication for mild-to-moderate pain. Percocet, however, is an opioid because it contains oxycodone. It also contains acetaminophen (Tylenol), which is available OTC on its own. Percocet is available only by prescription and it’s usually reserved for pain that can’t be relieved by non-opioid pain medications. Common ibuprofen side effects include nausea, heartburn, and stomach pain. It can also cause kidney damage, stomach ulcers, and heart problems, but this is rare. Common Percocet side effects include nausea, constipation, and drowsiness. Its riskier side effects can include misuse, breathing problems, and overdose. It can also cause liver damage when used in large amounts due to the acetaminophen ingredient.

Ibuprofen

 

Get free coupons

Percocet

(oxycodone / acetaminophen)

Get free coupons

Summary for Ibuprofen

Prescription or over-the-counter

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that's used to temporarily relieve fever, pains, and aches in adults and children. In general, ibuprofen is taken by mouth every 4 to 8 hours, though the dosage depends on your age, weight, and other medical problems. Ibuprofen side effects include nausea, heartburn, and stomach pain, but taking it with food might help prevent these side effects. Ibuprofen is available over the counter and by prescription, depending on the strength you need.

Indications for Ibuprofen

Over-the-counter ibuprofen:

Prescription ibuprofen:

Pros and Cons for Ibuprofen

Pros

  • Works well for fever, pain, and swelling
  • Available over the counter and by prescription and as lower-cost generics
  • Available as tablets, capsules, chewable tablets, and an oral liquid
  • Chewable tablets and liquid can be used in children

Cons

  • Lasts for only about 6 hours, so might need to take multiple doses throughout the day
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems
  • Has risk of stomach bleeding, stomach ulcers, and kidney problems
  • Shouldn't take other NSAIDs at the same time because of higher risk for side effects

Common Side Effects for Ibuprofen

The following side effects were reported in up to 9% of people in clinical studies.

  • Nausea
  • Stomach pain
  • Heartburn
  • Dizziness
  • Rash

Warnings for Ibuprofen

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions
  • Harm to unborn babies
  • Caution use in people with phenylketonuria (PKU) - chewable tablets only

Summary for Percocet

Prescription only

Percocet (oxycodone / acetaminophen) is a combination opioid medication. It's used to treat pain when non-opioid medications aren't working well enough to control pain. It's a controlled substance because it has a high risk of misuse, dependency, and addiction.

Indications for Percocet

  • Pain that isn't relieved by non-opioid pain medications alone

Pros and Cons for Percocet

Pros

  • Can provide pain relief within 10 to 30 minutes
  • Available in a liquid form for people who have trouble swallowing pills
  • Available as a lower-cost, generic medication

Cons

  • High risk of misuse and dependency
  • Must slowly lower the dose to stop the medication after long-term use to avoid withdrawal symptoms
  • Not recommended to take with other medications containing acetaminophen since it can raise the risk of liver damage
  • A controlled medication, so there are special requirements to get a prescription filled

Common Side Effects for Percocet

  • Dizziness
  • Sleepiness
  • Nausea
  • Vomiting
  • Constipation
  • Itching

Warnings for Percocet

  • Potential for addiction and misuse
  • Dangerously slow breathing (respiratory depression)
  • Opioid overdose
  • Difficulty concentrating and extreme sleepiness
  • Liver damage
  • Drug interactions
  • Harm to newborn babies
  • Severe allergic and skin reactions
  • Physical dependence and withdrawal
  • Low blood pressure
  • Low adrenal hormone levels
  • Seizures

Prices with our coupons for Ibuprofen vs. Percocet

Price Card Drug Icon
Ibuprofen30 tablets / 800mg
$8.92$16.20
Get free coupons
More Information
Price Card Drug Icon
Oxycodone/Acetaminophen90 tablets / 5mg/325mg
$24.65$60.64
Get free coupons
More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.