Key takeaways
Ibuprofen (Advil, Motrin) and indomethacin (Indocin) are both NSAIDs used to relieve pain and inflammation, but they have some key differences. Ibuprofen is available over-the-counter and by prescription, while indomethacin requires a prescription. Ibuprofen can be taken orally in various forms like tablets, capsules, and liquid, whereas indomethacin is available as a tablet and rectal suppository. Ibuprofen is commonly used for short-term relief of minor aches, pains, and fever, while indomethacin is used for more severe conditions like rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis. Side effects for both include stomach upset and headache, but indomethacin can also cause rectal irritation when used as a suppository. Additionally, ibuprofen is more accessible and comes in multiple strengths, while indomethacin is only available in a 50 mg or 75 mg strength. Neither medication should be taken together or with other NSAIDs due to increased risks of side effects like stomach bleeding and kidney damage.
