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Fosamax vs. Evista

Alendronate sodium (Fosamax) is a bisphosphonate that prevents and treats osteoporosis. It works by slowing the breakdown of bones so that the body has a chance to build up more bone; this strengthens bones and lowers the risk of fractures. Alendronate (Fosamax) is taken by mouth, either daily or weekly dosing, depending on your dose. In addition to the tablet, it's also available as an oral solution and a dissolvable tablet (brand name Binosto). Some common side effects of alendronate (Fosamax) can include stomach pain, heartburn, and bone or muscle pain.

• Prevention and treatment of osteoporosis in females
• Treatment of osteoporosis in males
• Paget's disease

• Stomach pain (up to 7%)
• Muscle, bone, and joint pain (up to 4%)
• Heartburn or indigestion (up to 4%)
• Nausea (up to 4%)
• Passing gas (up to 4%, more common with daily dose)

• Irritation and ulcers of the stomach and esophagus
• Lower calcium levels
• Muscle Pain
• Jaw bone problems
• Leg bone fractures
• Not recommended in people with serious kidney problems

Raloxifene (Evista) is used to treat osteoporosis (bone loss) and lower the risk of breast cancer in women who've gone through menopause. This medication belongs to the drug class known as selective estrogen receptor modulators (SERMs). Raloxifene (Evista) is a tablet that's taken once a day. Side effects can include hot flashes, headaches, and joint pain.

• Osteoporosis in women who've gone through menopause (postmenopausal)
• Lower the risk of invasive breast cancer in postmenopausal women who are at high risk for breast cancer or who have osteoporosis

• Joint pain (16%)
• Flu-like symptoms (14%)
• Hot flashes (10%)
• Bronchitis (10%)
• Runny nose (10%)
• Cough (9%)
• Headache (9%)
• Nausea (8%)
• Sinus infection (8%)
• Leg cramps (7%)
• Diarrhea (7%)
• Swelling in the arms or legs (5%)

• Higher risk for blood clots and stroke
• High triglyceride levels
• Continue to monitor for breast cancer
• Interaction with warfarin (Coumadin)