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Flexeril vs. Xanax

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cyclobenzaprine (Flexeril) and alprazolam (Xanax) are both medications that can help with certain conditions, but they belong to different drug classes and have different uses. Cyclobenzaprine is a muscle relaxant used to treat muscle pain and discomfort, while alprazolam is a benzodiazepine used to treat generalized anxiety disorder (GAD) and panic disorder. Cyclobenzaprine is available as immediate-release tablets and extended-release capsules, and it is not a controlled substance. Alprazolam, on the other hand, is a Schedule IV controlled medication and comes in immediate-release tablets, orally disintegrating tablets, and oral solution forms. Cyclobenzaprine can cause drowsiness and dry mouth, and it should not be mixed with alcohol due to increased drowsiness. Alprazolam can also cause drowsiness and memory problems, and it carries a risk of dependence and withdrawal symptoms if stopped suddenly. Cyclobenzaprine is typically used for short-term treatment (up to 2 to 3 weeks). Alprazolam is also meant for short-term use to avoid dependence. Both medications should be used with caution, especially if you are taking other medications that cause drowsiness or if you have liver problems.

Cyclobenzaprine

 

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Alprazolam

(Xanax)

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Summary for Flexeril

Prescription only

Cyclobenzaprine is a muscle relaxant that helps relieve muscle pain and discomfort. It's often used short term with rest and physical therapy. Immediate-release tablets are for people 15 years and older and are taken a few times a day. Once sold under the brand name Flexeril, the tablets now as a generic and brand name Fexmid. Extended-release capsules are for adults only and are taken once a day. The capsules comes as a generic and brand name Amrix. Cyclobenzaprine can make you sleepy and have dry mouth as side effects.

Indications for Flexeril

  • Muscle discomfort from short-term muscle or bone injury problems

Pros and Cons for Flexeril

Pros

  • Can take with or without food
  • Available as short-acting and long-acting forms for flexible dosing schedules
  • Can help with recovery from acute painful muscle problems in a few days

Cons

  • Only meant for short-term use (up to 2 to 3 weeks at a time)
  • Might not be a safe option for older adults
  • Not known to work well for nerve pain or muscle spasms caused by brain or spinal injuries

Common Side Effects for Flexeril

Immediate-release tablets:

  • Drowsiness (39%)
  • Dry mouth (27%)
  • Dizziness (11%)

Extended-release capsules:

  • Dry mouth (14%)
  • Dizziness (6%)

Warnings for Flexeril

  • Serotonin syndrome
  • Effect on driving and concentration
  • Caution use in people with glaucoma or trouble urinating
  • Caution use in people with liver problems

Summary for Xanax

Prescription only

Alprazolam (Xanax) is a benzodiazepine. It's approved to treat generalized anxiety disorder (GAD) and panic attacks in adults. It's taken by mouth, typically 3 times a day or as directed by your healthcare team. To avoid the risk of dependence, alprazolam (Xanax) is meant for short-term treatment only. Some of the more common side effects of this medication include drowsiness and memory problems. You should avoid drinking alcohol while taking alprazolam (Xanax) because this can lead to serious interactions.

Indications for Xanax

Pros and Cons for Xanax

Pros

  • Taken by mouth
  • Can start to work in 30 minutes
  • Available as quick-dissolving tablets or liquid for people who have trouble swallowing pills

Cons

Common Side Effects for Xanax

Generalized anxiety disorder:

  • Drowsiness (41%)
  • Lightheadedness (21%)
  • Dry mouth (15%)

Panic disorder:

  • Drowsiness (77%)
  • Fatigue (49%)
  • Poor coordination (40%)
  • Memory issues (33%)
  • Irritability (33%)
  • Appetite changes (28-33%)
  • Thinking problems (29%)
  • Constipation (26%)

Side effects listed are for the immediate-release forms. Side effects for extended-release form might differ.

Warnings for Xanax

  • Sedation and difficulty breathing
  • Potential for misuse, addiction, dependence, and withdrawal
  • Effect on driving and concentration
  • Harm to babies
  • Interactions with other medications
  • Use with caution in people with depression

Prices with our coupons for Flexeril vs. Xanax

Price Card Drug Icon
Cyclobenzaprine30 tablets / 10mg
$8.90$30.69
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Alprazolam30 tablets / 0.5mg
$10.40$14.84
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