Key takeaways
Metronidazole (Flagyl) and clotrimazole vaginal cream are used to treat different types of infections. Metronidazole (Flagyl) is an oral antibiotic that treats bacterial and parasitic infections, such as bacterial vaginosis and trichomoniasis. It is taken by mouth, usually three times a day, and is available as a lower-cost generic. Common side effects include diarrhea, nausea, and vomiting, and you should avoid alcohol while taking it. On the other hand, clotrimazole vaginal cream is an over-the-counter antifungal medication used to treat vaginal yeast infections. It is applied inside the vagina or on the surrounding skin, typically once a day at bedtime for 3 or 7 days, depending on the strength. Clotrimazole can cause vaginal irritation, itching, and burning. Unlike metronidazole, clotrimazole is not taken orally and does not have serious interactions with alcohol. Both medications are available as generics, but they treat different types of infections and are used in different ways.
