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Evenity vs. Forteo

Evenity (romosozumab or romosozumab-aqqg) is an injection used to treat osteoporosis (bone loss) in certain women after menopause. These women either have a high risk of fracture or can’t take other medications for bone loss. It's also used when these other medications haven’t worked well enough. Evenity (romosozumab) belongs to the drug class called sclerostin inhibitors. It works to help your bones grow and prevent bone breakdown at the same time. The injection is given once a month by a healthcare professional. Common side effects are joint pain and headache. There's also serious risks of heart attack and stroke. This medication is brand name only; there's no generic available yet.

• Treatment of osteoporosis in certain women after menopause
  • With high risk of fracture
  • Who can’t take other medications for bone loss
  • Who tried other medications for bone loss that didn’t work

• Joint pain (up to 13%)
• Headache (up to 7%)

• Risk of heart attack, stroke, or heart-related death
• Low calcium levels (hypocalcemia)
• Risk of problems in the jawbone (osteonecrosis of the jaw)
• Risk of fractures in the thigh

Forteo (teriparatide) is used to treat osteoporosis (bone loss or weakening). It's for people who are at very high fracture risk or people who've already tried other osteoporosis medications. Forteo (teriparatide) is an injection that you give to yourself once a day. Some common side effects include general body pain and joint pain. This medication comes as a prefilled pen, but it doesn't come with pen needles. Forteo (teriparatide) is only available as a brand medication; there's no generic version yet.

• Osteoporosis in females who've gone through menopause (postmenopause)
• Osteoporosis in males
• Osteoporosis caused by long-term use of corticosteroids

• Body pain (21%)
• Joint pain (10%)
• Runny nose (10%)
• Nausea (9%)
• Body weakness (9%)
• Headache (8%)
• Dizziness (8%)
• High blood pressure (7%)

• Bone cancer (osteosarcoma)
• High calcium levels in the blood
• Kidney stones
• Low blood pressure
• Higher risk of side effects from digoxin (Lanoxin)