Key takeaways
Selegiline (Zelapar) and Stalevo (carbidopa/levodopa/entacapone) are both used to treat Parkinson's disease (PD), but they work differently and have different uses. Selegiline is a monoamine oxidase type B (MAO-B) inhibitor that helps prevent the breakdown of dopamine in your brain, extending the effects of levodopa. It's used as an add-on treatment for people already taking carbidopa and levodopa. Stalevo, on the other hand, combines three medications: carbidopa, levodopa, and entacapone. This combination helps levodopa reach higher levels in your brain and stay effective longer, reducing "off" periods when symptoms return. Selegiline is available in tablets, capsules, and orally disintegrating tablets (ODTs), while Stalevo is available in multiple strengths but only as a tablet. Selegiline can cause high blood pressure if you eat foods high in tyramine, while Stalevo can cause diarrhea and dark-colored bodily fluids. Both medications can cause sleepiness and hallucinations, but Stalevo also has a rare risk of severe muscle damage. Selegiline is available in a lower-cost generic form, while the ODT version is only available as a brand name.
