Key takeaways
Methamphetamine (Desoxyn) and methylphenidate extended-release (ER) (Concerta, Ritalin LA) are both stimulant medications used to treat attention deficit-hyperactivity disorder (ADHD). Methamphetamine is less commonly prescribed due to its higher risk of addiction and dependence, while methylphenidate ER is a first-choice option for ADHD. Methamphetamine works by raising levels of norepinephrine, serotonin, and dopamine in the brain, whereas methylphenidate ER primarily affects norepinephrine and dopamine, with some impact on serotonin. Methamphetamine is only available as a tablet and might need to be taken twice daily, while methylphenidate ER comes in various forms, including tablets, capsules, chewable tablets, and liquid, and is typically taken once a day. Both medications have similar side effects, such as high blood pressure and trouble sleeping, but methamphetamine has additional risks like severe heart problems and changes in behavior or thoughts. Methylphenidate ER is available in many generic forms, making it more accessible and potentially more affordable.
