Key takeaways
Dextromethorphan (Delsym) and acetaminophen / dextromethorphan / doxylamine (Vicks Nyquil Cold and Flu) are both over-the-counter medications used to relieve cough. Dextromethorphan is an antitussive, specifically for short-term relief of cough caused by minor throat or lung irritation, like the common cold. It comes in extended-release and immediate-release forms, taken every 12 hours or every 6 to 8 hours, respectively. On the other hand, Nyquil is a combination medication that includes acetaminophen for pain and fever, dextromethorphan for cough, and doxylamine, an antihistamine, for symptoms like runny nose and sneezing. Nyquil is available as a liquid or capsules and is typically taken every 6 hours. While Delsym is primarily focused on cough relief, Nyquil addresses a broader range of cold and flu symptoms. Both medications can cause drowsiness, but Nyquil is more likely to make you sleepy due to the antihistamine. Additionally, Nyquil carries a risk of liver damage if taken with other acetaminophen-containing products, while Delsym can interact with certain antidepressants, leading to serotonin syndrome.
