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Claritin vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Loratadine (Claritin) and cetirizine (Zyrtec) are both second-generation antihistamines used to relieve allergy symptoms like runny nose and watery eyes, but they have some differences. Loratadine is less likely to cause drowsiness compared to cetirizine, which can make you feel sleepy. Both medications are available over-the-counter and are typically considered safe during pregnancy. Both medications come in various forms, such as tablets and liquid solutions, and are typically taken once a day. However, cetirizine starts working faster, within 20 to 60 minutes, while loratadine may take 1 to 3 hours to start relieving symptoms. Additionally, cetirizine is approved for treating chronic hives in young children, whereas loratadine is not specifically indicated for this use.

Loratadine

(Claritin)

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Cetirizine

(Zyrtec)

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Summary for Claritin

Over-the-counter

Loratadine (Claritin) is an over-the-counter antihistamine for adults and kids. It helps relieve allergy symptoms like a runny nose, sneezing, and watery eyes. This allergy medication is taken by mouth, usually once a day. It comes as different formulations, including regular tablets, chewable tablets, and a liquid. Loratadine (Claritin) is a non-drowsy allergy medication because it's less likely to make you sleepy. Other side effects can include headache and feeling tired. Loratadine (Claritin) is available as a brand-name and generic.

Indications for Claritin

  • Short-term relief of allergy symptoms (runny nose, itchy nose or throat, itchy or watery eyes)

Pros and Cons for Claritin

Pros

Cons

  • Can take 1 to 3 hours to start working
  • Regular tablets and quick-dissolving tablets not for children younger than 6
  • Might have a higher risk of side effects if you have liver or kidney problems

Common Side Effects for Claritin

  • Headache (12%)
  • Sleepiness (8%)
  • Feeling tired (4%)
  • Dry mouth (3%)

Warnings for Claritin

  • Sleepiness
  • Accidentally taking too much medication
  • Caution use in people with phenylketonuria (PKU) - chewable tablets and orally disintegrating tablets

Summary for Zyrtec

Prescription or over-the-counter

Cetirizine (Zyrtec) is an antihistamine. It's used for relief of allergy symptoms, such as runny nose or watery eyes, in adults and children. Cetirizine (Zyrtec) is also a safe option for people who are pregnant. This medication is available in different formulations, including tablets and liquid solutions. Typically, cetirizine (Zyrtec) is taken by mouth once per day. The most common side effect of cetirizine (Zyrtec) is sleepiness. But it's less likely to make you drowsy compared to some other antihistamines, such as diphenhydramine (Benadryl).

Indications for Zyrtec

  • Short-term relief of allergy symptoms (sneezing, runny nose, itchy or watery eyes, itching of the nose or throat)
  • Relief of itchiness due to chronic (long-term) hives in children ages 6 months to under 6 years old - certain liquid solutions only

Pros and Cons for Zyrtec

Pros

  • First-choice option for relieving allergy symptoms
  • Taken once per day
  • Available in several formulations (e.g., pills, chewable tablets, orally disintegrating tablets, liquids)
  • Safe to take while pregnant

Cons

  • Can cause you to feel sleepy
  • Higher risk of side effects in people with liver or kidney problems
  • Pills can't be used in children younger than 6 years.

Common Side Effects for Zyrtec

People 12 years of age and older:

  • Sleepiness (14%)
  • Tiredness (6%)
  • Dry mouth (5%)

Children age 6 to under 12 years:

  • Headache (11-14%)
  • Sore throat (3-6%)
  • Stomach pain (4-6%)
  • Cough (3-4%)
  • Sleepiness (2-4%)

Warnings for Zyrtec

  • Sleepiness
  • Accidentally taking too much medication

Prices with our coupons for Claritin vs. Zyrtec

Price Card Drug Icon
Loratadine30 tablets / 24 hour
$9.17$9.17
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Cetirizine90 tablets / 24 hour of 10mg
$9.11$14.04
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