Key takeaways
Loratadine (Claritin) and cetirizine (Zyrtec) are both second-generation antihistamines used to relieve allergy symptoms like runny nose and watery eyes, but they have some differences. Loratadine is less likely to cause drowsiness compared to cetirizine, which can make you feel sleepy. Both medications are available over-the-counter and are typically considered safe during pregnancy. Both medications come in various forms, such as tablets and liquid solutions, and are typically taken once a day. However, cetirizine starts working faster, within 20 to 60 minutes, while loratadine may take 1 to 3 hours to start relieving symptoms. Additionally, cetirizine is approved for treating chronic hives in young children, whereas loratadine is not specifically indicated for this use.
