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Ciprofloxacin vs. Cephalexin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ciprofloxacin (Cipro) and cephalexin are both antibiotics used to treat bacterial infections, including urinary tract infections (UTIs) and sinus infections. However, they belong to different medication classes. Ciprofloxacin is a fluoroquinolone antibiotic, while cephalexin is a cephalosporin antibiotic. Ciprofloxacin is typically taken twice a day and is available as a pill, oral solution, and injection, whereas cephalexin is taken 2 to 4 times a day and comes in capsules, tablets, and liquid suspensions. Ciprofloxacin is often reserved for more serious infections due to its potential for serious side effects, such as tendon rupture and nerve damage. Cephalexin, on the other hand, is generally considered safer and is available as a lower-cost generic. Common side effects of both medications include nausea, vomiting, and diarrhea. Both medications can interact with many medications, including metformin, probenecid and warfarin.

Ciprofloxacin

(Cipro)

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Cephalexin

 

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Summary for Ciprofloxacin

Prescription only

Ciprofloxacin (Cipro) is a fluoroquinolone antibiotic. It can treat many types of bacterial infections, including sinus infections and urinary tract infections (UTIs). But because ciprofloxacin (Cipro) can cause serious side effects, such as tendon rupture and nerve damage, it's usually only prescribed for more serious infections or when there aren't any safer options. Ciprofloxacin (Cipro) is taken by mouth, typically twice daily. It's available as a pill and oral solution. Some of the more common side effects of this medication include nausea and diarrhea.

Indications for Ciprofloxacin

Adults only

Adults and children

Pros and Cons for Ciprofloxacin

Pros

  • Can take with or without food
  • Available as tablets, oral liquid, and injection
  • Possible option for people with penicillin allergy

Cons

Common Side Effects for Ciprofloxacin

  • Nausea
  • Diarrhea
  • Vomiting
  • Rash
  • Abnormal liver blood test results

Warnings for Ciprofloxacin

  • Tendon inflammation and rupture
  • Effects on the brain, nerves, and mental health
  • Worsening of myasthenia gravis
  • Severe allergic and skin reactions
  • Liver damage
  • Severe damage to a major blood vessel
  • Infectious diarrhea
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Muscle, bone, or joint problems in children
  • Sun and light sensitivity
  • Kidney problems

Summary for Cephalexin

Prescription only

Cephalexin, also commonly known as Keflex, is a cephalosporin antibiotic for people ages 1 year and older. It can treat many types of bacterial infections. This includes ear infections, skin infections like cellulitis, urinary tract infections (UTIs), and strep throat. Cephalexin comes as capsules, tablets, and a liquid suspension. It's taken by mouth 2 to 4 times per day. Side effects can include nausea, vomiting, and diarrhea. Cephalexin is a generic medication; its brand name Keflex is no longer available.

Indications for Cephalexin

Pros and Cons for Cephalexin

Pros

  • Treats several common types of bacterial infections
  • Okay for children as young as 1 year old to take
  • Available as a liquid for people who have trouble swallowing pills

Cons

  • Usually need to take a few times per day
  • Might not be able to take if you're allergic to penicillins or other cephalosporin antibiotics
  • Not recommended for the cold or flu (these are viral illnesses, not bacterial infections)

Common Side Effects for Cephalexin

  • Diarrhea
  • Nausea
  • Vomiting
  • Indigestion
  • Stomach pain

Warnings for Cephalexin

  • Allergic reactions
  • Diarrhea from Clostridioides difficile infection
  • Seizures
  • Higher risk of bleeding
  • Possible development of drug-resistant bacteria

Prices with our coupons for Ciprofloxacin vs. Cephalexin

Price Card Drug Icon
Ciprofloxacin14 tablets / 500mg
$10.88$13.08
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Cephalexin28 capsules / 500mg
$10.68$29.98
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