Key takeaways
Chlorzoxazone (Lorzone) and Cyclobenzaprine (Flexeril) are both muscle relaxants used to treat muscle pain and discomfort, but they have some key differences. Chlorzoxazone is typically used for sudden muscle pain and is taken three to four times a day, while Cyclobenzaprine is used for acute muscle discomfort and is available in both immediate-release (IR) tablets taken three times a day and extended-release (ER) capsules taken once a day. Chlorzoxazone works by blocking the nerves that cause muscle cramps, whereas Cyclobenzaprine works in the brain to relieve muscle spasms. Cyclobenzaprine can cause dry mouth and has a risk of serotonin syndrome when taken with certain medications, while Chlorzoxazone can cause severe liver damage in rare cases. Both medications can cause drowsiness and dizziness. Additionally, Cyclobenzaprine is not recommended for people with certain heart conditions or liver problems, whereas Chlorzoxazone does not have these specific contraindications.
