Key takeaways
Cephalexin (Keflex) and Clindamycin (Cleocin) are both antibiotics used to treat bacterial infections, but they belong to different medication classes. Cephalexin is a cephalosporin antibiotic, while Clindamycin is a lincosamide antibiotic. Both medications can treat skin infections and bone infections, but Clindamycin is also used for more serious infections like lower respiratory tract infections and bloodstream infections. Cephalexin is available as capsules, tablets, and liquid suspensions, and is typically taken 2 to 4 times a day. Clindamycin is available as capsules, liquid, and injections, and is usually taken 3 to 4 times a day. Both medications are available as lower-cost generics. Common side effects of Cephalexin include nausea, vomiting, and diarrhea, while Clindamycin can cause stomach upset, itching, and rash. Both medications can cause a serious type of diarrhea related to *Clostridioides difficile* infection. Cephalexin may interact with metformin and probenecid, while Clindamycin can interact with medications like warfarin and amiodarone.
