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Cefdinir vs. Cipro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cefdinir (Omnicef) and ciprofloxacin (Cipro) are both antibiotics used to treat bacterial infections, including sinus infections. However, they belong to different medication classes. Cefdinir is a cephalosporin antibiotic, while ciprofloxacin is a fluoroquinolone antibiotic. Cefdinir is available as capsules and oral suspension, and it is typically taken once or twice a day. Ciprofloxacin comes in tablets, oral solution, and injection forms, and is usually taken twice daily. Both medications are used for children and adults, while ciprofloxacin is generally reserved for more serious infections due to its potential for serious side effects, such as tendon rupture and nerve damage. Common side effects of cefdinir include diarrhea and nausea, whereas ciprofloxacin can cause nausea, diarrhea, and more severe issues like abnormal heart rhythms and liver problems. Both medications can interact with supplements like calcium and iron, but ciprofloxacin has a broader range of drug interactions.

Cefdinir

 

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Ciprofloxacin

(Cipro)

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Summary for Cefdinir

Prescription only

Cefdinir, also known by its brand name Omnicef, is a cephalosporin antibiotic that can treat several types of bacterial infections, such as pneumonia, sinus infections, and ear infections. Although the brand name is no longer available, its generic can still be prescribed for adults and children. Cefdinir comes as capsules and a suspension that are taken once or twice per day by mouth. Side effects can include diarrhea, nausea, and rash.

Indications for Cefdinir

Pros and Cons for Cefdinir

Pros

  • Available as a capsule and oral suspension
  • Can be used for children and adults
  • Might be able to take once per day, depending on the infection
  • Can keep oral suspension at room temperature for up to 10 days

Cons

  • Might not be able to take this antibiotic if you've had a severe allergic reaction to penicillins or other cephalosporin antibiotics
  • Must separate when you take cefdinir and antacids or iron supplements by at least 2 hours
  • Oral suspension contains sugar, so people with diabetes might have higher blood sugar levels while they're taking the antibiotic
  • Not recommended for the cold or flu, since they're not caused by a bacterial infection

Common Side Effects for Cefdinir

  • Diarrhea (up to 15%)

Warnings for Cefdinir

  • Severe allergic reactions
  • Diarrhea from Clostridioides difficile infection
  • Possible development of drug-resistant bacteria

Summary for Cipro

Prescription only

Ciprofloxacin (Cipro) is a fluoroquinolone antibiotic. It can treat many types of bacterial infections, including sinus infections and urinary tract infections (UTIs). But because ciprofloxacin (Cipro) can cause serious side effects, such as tendon rupture and nerve damage, it's usually only prescribed for more serious infections or when there aren't any safer options. Ciprofloxacin (Cipro) is taken by mouth, typically twice daily. It's available as a pill and oral solution. Some of the more common side effects of this medication include nausea and diarrhea.

Indications for Cipro

Adults only

Adults and children

Pros and Cons for Cipro

Pros

  • Can take with or without food
  • Available as tablets, oral liquid, and injection
  • Possible option for people with penicillin allergy

Cons

Common Side Effects for Cipro

  • Nausea
  • Diarrhea
  • Vomiting
  • Rash
  • Abnormal liver blood test results

Warnings for Cipro

  • Tendon inflammation and rupture
  • Effects on the brain, nerves, and mental health
  • Worsening of myasthenia gravis
  • Severe allergic and skin reactions
  • Liver damage
  • Severe damage to a major blood vessel
  • Infectious diarrhea
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Muscle, bone, or joint problems in children
  • Sun and light sensitivity
  • Kidney problems

Prices with our coupons for Cefdinir vs. Cipro

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Cefdinir20 capsules / 300mg
$19.90$68.56
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Ciprofloxacin14 tablets / 500mg
$10.88$13.08
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