Key takeaways
Cefdinir (Omnicef) and cefpodoxime (Vantin) are both cephalosporin antibiotics used to treat bacterial infections like pneumonia, sinus infections, and strep throat. While they share these uses, cefdinir is also commonly used off-label for urinary tract infections (UTIs) in children, whereas cefpodoxime is FDA-approved for UTIs in children and adults. Cefdinir is available as capsules and oral suspension, typically taken once or twice a day, while cefpodoxime comes in tablets and suspension, usually taken twice a day. Both medications are available as generics since their brand names are discontinued. Common side effects for both include diarrhea and nausea, but cefdinir may cause a rash more frequently, while cefpodoxime can lead to diaper rash in children. You should avoid taking antacids or iron supplements close to cefdinir, as they can interfere with its absorption, whereas cefpodoxime should be taken with food to improve absorption. Both medications carry a risk of severe allergic reactions, especially if you have a penicillin allergy, and can cause serious diarrhea related to *C. difficile* infection.
