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Cabtreo vs. Adapalene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cabtreo (clindamycin/adapalene/benzoyl peroxide) and Differin (adapalene) are both topical medications used to treat acne. They share the active ingredient adapalene, a retinoid that helps unclog pores and reduce inflammation. However, Cabtreo is a combination medication that also includes clindamycin, an antibiotic, and benzoyl peroxide, an antiseptic, making it suitable for treating a broader range of acne types. Differin, on the other hand, is available both as a prescription and over-the-counter in various forms like cream, gel, and lotion, while Cabtreo is only available as a prescription gel. Cabtreo is applied once daily, and its common side effects include pain, redness, and dryness at the application site. Differin can also cause skin irritation, burning, and itching, but these effects are generally less severe. Both medications can make your skin more sensitive to the sun, so using sunscreen is important. Cabtreo does not have a generic version, whereas Differin's 0.1% gel is available over-the-counter, making it more accessible.

Cabtreo

 

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Differin

(adapalene)

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Summary for Cabtreo

Prescription only

Cabtreo is a combination medication that’s made up of three active ingredients: clindamycin (an antibiotic), adapalene (a retinoid), and benzoyl peroxide (an antiseptic). These ingredients work together to treat acne in people 12 years of age and older. Cabtreo is a topical gel that’s applied as a thin layer onto the face once daily. Common side effects of the medication include pain, redness, and dryness at the site of application.

Indications for Cabtreo

Pros and Cons for Cabtreo

Pros

  • Three medications that treat acne in one product, so it’s convenient
  • Applied to the skin
  • Approved for children ages 12 years and older

Cons

  • Uncomfortable side effects like pain at the application site and skin peeling
  • Skin can become sensitive to the sun, which can increase the likelihood of sunburns
  • May bleach your hair, clothing, and bedding

Common Side Effects for Cabtreo

  • Pain at the application site (14%)
  • Skin redness (5%)
  • Dry skin (4%)
  • Skin irritation (2%)
  • Skin peeling or flaky skin (2%)

Warnings for Cabtreo

  • Serious gut problems
  • Skin that's sensitive to sunlight
  • Skin irritation

Summary for Adapalene

Prescription or over-the-counter

Differin (adapalene) works well for treating mild-to-moderate acne. Differin (adapalene) can cause skin irritation, burning, and itching right after using it, so make sure you have moisturizer with you to help with this side effect. This acne treatment has different strengths and formulations (e.g., cream, gel, lotion). But only the lower strength gel is available over the counter.

Indications for Adapalene

  • Acne

Pros and Cons for Adapalene

Pros

  • A first-choice option for treating acne
  • Only need to apply once a day
  • Safe to use for acne in children 12 and older
  • The 0.1% gel is available without a prescription.

Cons

  • Can get sunburns more easily
  • Can make skin dry, itchy, and flaky
  • Can take up to 12 weeks to see full effects
  • Skin might look worse before it starts looking better

Common Side Effects for Adapalene

  • Dry skin (up to 45%)
  • Scaling or peeling (up to 44%)
  • Stinging or burning (up to 29%)
  • Skin redness (up to 26%)

Warnings for Adapalene

  • Allergic reactions
  • Sunburn
  • Skin irritation

Prices with our coupons for Cabtreo vs. Adapalene

Price Card Drug Icon
Cabtreo1 pump / 50g of 1.2%/0.15%/3.1%
$918.25$1,176.19
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Price Card Drug Icon
Adapalene1 tube / 45g of 0.3%
$37.35$270.22
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