Key takeaways
Amoxicillin/clavulanate (Augmentin) and azithromycin (Zithromax) are both antibiotics used to treat various bacterial infections, such as sinus infections and skin infections. However, they belong to different medication classes. Amoxicillin-clavulanate is a penicillin antibiotic combined with a beta-lactamase inhibitor, while azithromycin is a macrolide antibiotic. Augmentin is available in tablets, chewable tablets, and liquid suspensions, and is typically taken two to three times daily. In contrast, Zithromax is taken once daily, often for a shorter duration of 3 to 5 days, and is available as tablets and liquid suspension. Both medications are available as lower-cost generics. Both medications can cause side effects like diarrhea and nausea, but azithromycin may also lead to stomach pain and QT prolongation, a heart rhythm problem. Both medications can interact with warfarin, while Zithromax can also interact with antiarrhythmics and statins, potentially leading to serious heart rhythm issues.
